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Cord Factor

[(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[2-[1-hydroxy-12-(2-octadecylcyclopropyl)dodecyl]hexacosanoyloxymethyl]oxan-2-yl]oxyoxan-2-yl]methyl 2-[1-hydroxy-12-(2-octadecylcyclopropyl)dodecyl]hexacosanoate · also: Cord Factors, Trehalose 6,6 inverted exclamation marka-dimycolate

FormulaC130H250O15
Mol. weight2053.415
PubChem CID131750187
InChIKeyDNTVYCRMHZDZGU-MJSODCSWSA-N
SMILESCCCCCCCCCCCCCCCCCCCCCCCCC(C(CCCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC)O)C(=O)OC[C@@H]2[C@H]([C@@H]([C@H]([C@H](O2)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)COC(=O)C(CCCCCCCCCCCCCCCCCCCCCCCC)C(CCCCCCCCCCCC4CC4CCCCCCCCCCCCCCCCCC)O)O)O)O)O)O)O
114Patents
505Research papers
27Patents - last 3 years
14Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Adcock Ingram Ltd3
2Royal Melbourne Institute of Technology3
3Melbourne Institute of Technology2
4Academia Sinica1
5Access to Advanced Health Institute1
6Albert Einstein College of Medicine1
7Bekaert NV SA1
8Colorado State University Research Foundation1
9Consejo Superior de Investigaciones Científicas1
10Ford Motor Co1

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1G01NInvestigating / analysing materials47
2A61KMedicinal preparations46
3A61PTherapeutic activity (drug indications)30
4C07HSugars and derivatives30
5C12NMicroorganisms, enzymes18
6C07KPeptides14
7C07CAcyclic and carbocyclic compounds12
8C09KMaterials for misc. applications12
9Y02AClimate change adaptation10
10C07DHeterocyclic compounds9

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
PSEUDO-AMIDE CORD FACTORS IN THE SERODIAGNOSIS OF TUBERCULOSIS IN ANIMALS1995INFLAZYME PHARMACEUTICALS LTD.0
Mirror amide cord factors and mirror thioester cord factors for diagnosis of tuberculosis1995INFLAZYME PHARMACEUTICALS, INC.0
Mirror amide cord factors and mirror thioester cord factors for diagnosis of tuberculosis1994INFLAZYME PHARMACEUTICALS CANADA INC.0
MIRROR AMIDE CORD FACTORS AND MIRROR THIOESTHER CORD FACTORS FOR DIAGNOSIS OF TUBERCULOSIS1994INFLAZYME PHARMACEUTICALS INC.0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Mycobacterium research and diagnosis3
2Tuberculosis Research and Epidemiology3
3Cutaneous lymphoproliferative disorders research1
4Cybercrime and Law Enforcement Studies1
5Design Education and Practice1
6Endometriosis Research and Treatment1
7Helicobacter pylori-related gastroenterology studies1
8Immune Cell Function and Interaction1
9Immune Response and Inflammation1
10Infant Nutrition and Health1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Ikuya YanoOsaka City University35
2E. LedererInstitut de Chimie des Substances Naturelles17
3E YarkoniNational Cancer Institute13
4Jeffrey K. ActorThe University of Texas Health Science Center at Houston13
5Robert L. HunterThe University of Texas Health Science Center at Houston13
6Ichiro AzumaHokkaido University11
7G. LemaireUniversité Paris-Sud10
8Célio Lopes SilvaUniversidade de São Paulo9
9A. BekierkunstHebrew University of Jerusalem8
10Nagatoshi FujiwaraOsaka City University8

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Cord Factor?

Cord Factor has the molecular formula C130H250O15 with a molecular weight of 2053.415. Its canonical chemical name is [(2R,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[2-[1-hydroxy-12-(2-octadecylcyclopropyl)dodecyl]hexacosanoyloxymethyl]oxan-2-yl]oxyoxan-2-yl]methyl 2-[1-hydroxy-12-(2-octadecylcyclopropyl)dodecyl]hexacosanoate, and it is also known as trehalose 6,6′-α-dimycolate.

What are the leading research topics and applications for Cord Factor?

Cord Factor research is primarily concentrated in tuberculosis diagnosis and research. Leading papers address its recognition by C-type lectin Mincle, its role in mycobacterial cell wall biogenesis, and its adjuvanticity properties. Notable applications include serodiagnosis of tuberculosis and use as a synthetic vaccine adjuvant analog.

Which institutions and organizations are most active in Cord Factor patent development?

The leading patent assignees are Adcock Ingram Ltd and Royal Melbourne Institute of Technology, each holding 3 patents. Melbourne Institute of Technology holds 2 patents. Other institutional assignees include Academia Sinica, Access to Advanced Health Institute, Albert Einstein College of Medicine, Bekaert NV SA, Colorado State University Research Foundation, Consejo Superior de Investigaciones Científicas, and Ford Motor Co, each with 1 patent.

Who are the most prolific researchers in Cord Factor studies?

Ikuya Yano from Osaka City University is the leading researcher with 35 papers, followed by E. Lederer from Institut de Chimie des Substances Naturelles with 17 papers. Other significant contributors include E Yarkoni from National Cancer Institute, Jeffrey K. Actor and Robert L. Hunter from The University of Texas Health Science Center at Houston, and Ichiro Azuma from Hokkaido University, each with 11–13 publications.

What is the scope of patent and publication activity on Cord Factor?

The research base includes 114 total patents and 505 papers. In the last three years (2023–2025), activity includes 27 patents and 14 papers. The most common patent classifications are G01N (diagnostic methods, 47 patents), A61K (medicinal preparations, 46 patents), and A61P (therapeutic uses, 30 patents), indicating strong focus on diagnostics and pharmaceutical applications.

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