cofactor - patents, research & applications

1,933Patents

223Research papers

295Patents - last 3 years

2Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#	Assignee	Patents
1	Danisco US Inc	144
2	Goodyear Tire and Rubber Co	92
3	BASF SE	83
4	EIDP Inc	67
5	Evonik Operations GmbH	35

6	Merck Patent GmbH	35
7	AbbVie Inc	32
8	Merck et Cie	20
9	McGill University	16
10	AbbVie Bahamas Ltd	14

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#	Code	Area	Patents
1	`A61K`	Medicinal preparations	687
2	`A61P`	Therapeutic activity (drug indications)	660
3	`C12N`	Microorganisms, enzymes	648
4	`C12P`	Fermentation, enzyme processes	580
5	`C07D`	Heterocyclic compounds	278

6	`C12Y`	Enzyme nomenclature (EC numbers)	277
7	`C12Q`	Measuring/testing involving enzymes	268
8	`C07K`	Peptides	210
9	`G01N`	Investigating / analysing materials	200
10	`Y02E`	Climate change mitigation: energy	192

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

Title	Year	Assignee	Cited by
Regulation of enzymes which utilize tetrahydrobiopterin or tetrahydrofolate cofactors with 6,6-disubstituted-tetrahydropteridines	1995	SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION	24
Cofactors and methods for use for individuals	2012	University of California San Diego UCSD	3
REGULATION OF ENZYMES WHICH UTILIZE TETRAHYDROBIOPTERIN OR TETRAHYDROFOLATE COFACTORS WITH 6, 6-DISUBSTITUTED-TETRAHYDROPTERIDINES	1991	SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION	0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#	Research topic	Papers
1	Folate and B Vitamins Research	5
2	Amino Acid Enzymes and Metabolism	1
3	Cancer Research and Treatments	1
4	Enzyme Structure and Function	1
5	Neuroscience and Neuropharmacology Research	1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#	Author	Affiliation	Papers
1	Daniel V. Santi	University of California, San Francisco	10
2	David G. Priest	Medical University of South Carolina	9
3	R. Bruce Dunlap	University of South Carolina	8
4	Rowena G. Matthews	University of Michigan	7
5	Amnon Kohen	University of Iowa	6

6	Elisabeth Odin	University of Gothenburg	5
7	Janet A. Houghton	St. Jude Children's Research Hospital	5
8	M.T. Doig	Medical University of South Carolina	5
9	Bengt Gustavsson	University of Gothenburg	4
10	Carmen J. Allegra	Naval Medical Research Command	4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Title	Year	Cited by	Topic
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase	1995	5715	Folate and B Vitamins Research
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.	1997	794	Epigenetics and DNA Methylation
Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.	1995	262	Folate and B Vitamins Research
Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate	1990	117	Colorectal Cancer Treatments and Studies
Determination of rates and yields of interchromophore (folate .fwdarw. flavin) energy transfer and intermolecular (flavin .fwdarw. DNA) electron transfer in Escherichia coli photolyase by time-resolved fluorescence and absorption spectroscopy	1991	112	Photosynthetic Processes and Mechanisms

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of this compound?

The compound has a molecular formula of C20H23N7O6 and a molecular weight of 457.447 g/mol.

Which organizations hold the most patents related to this compound?

The top patent assignees are Danisco US Inc with 144 patents, Goodyear Tire and Rubber Co with 92 patents, and BASF SE with 83 patents.

What are the leading research topics associated with this compound in academic literature?

The primary research topic is Folate and B Vitamins Research with 3 papers, followed by Amino Acid Enzymes and Metabolism, Cancer Research and Treatments, Enzyme Structure and Function, and Neuroscience and Neuropharmacology Research, each with 1 paper.

Who are the most prolific authors publishing on this compound?

The leading authors are Daniel V. Santi from University of California, San Francisco with 10 papers, David G. Priest from Medical University of South Carolina with 9 papers, and R. Bruce Dunlap from University of South Carolina with 8 papers.

What is the patent activity trend for this compound in recent years?

Patent filings increased significantly from 2022 onwards, peaking at 146 patents in 2023 and 141 in 2024, compared to 47–74 patents annually during 2016–2021. Recent years show an overall upward trend, though 2025 shows lower counts at 11 patents.