5,10-Methylene-5,6,7,8-tetrahydrofolic acid - patents, research & applications

1,933Patents

223Research papers

284Patents - last 3 years

2Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#	Assignee	Patents
1	Danisco US Inc	144
2	Goodyear Tire and Rubber Co	92
3	BASF SE	83
4	EIDP Inc	67
5	Evonik Operations GmbH	35

6	Merck Patent GmbH	35
7	AbbVie Inc	32
8	Merck & Cie	20
9	McGill University	16
10	AbbVie Bahamas Ltd	14

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#	Code	Area	Patents
1	`A61K`	Medicinal preparations	687
2	`A61P`	Therapeutic activity (drug indications)	661
3	`C12N`	Microorganisms, enzymes	648
4	`C12P`	Fermentation, enzyme processes	580
5	`C07D`	Heterocyclic compounds	278

6	`C12Y`	Enzyme nomenclature (EC numbers)	277
7	`C12Q`	Measuring/testing involving enzymes	268
8	`C07K`	Peptides	210
9	`G01N`	Investigating / analysing materials	202
10	`Y02E`	Climate change mitigation: energy	192

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#	Research topic	Papers
1	Folate and B Vitamins Research	6
2	Amino Acid Enzymes and Metabolism	1
3	Cancer Research and Treatments	1
4	Enzyme Structure and Function	1
5	Neuroscience and Neuropharmacology Research	1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#	Author	Affiliation	Papers
1	Daniel V. Santi	University of California, San Francisco	10
2	David G. Priest	Medical University of South Carolina	9
3	R. Bruce Dunlap	University of South Carolina	8
4	Rowena G. Matthews	University of Michigan	7
5	Amnon Kohen	University of Iowa	6

6	Elisabeth Odin	University of Gothenburg	5
7	Janet A. Houghton	St. Jude Children's Research Hospital	5
8	M.T. Doig	Medical University of South Carolina	5
9	Bengt Gustavsson	University of Gothenburg	4
10	Carmen J. Allegra	Naval Medical Research Command	4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Title	Year	Cited by	Topic
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase	1995	5719	Folate and B Vitamins Research
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.	1997	794	Epigenetics and DNA Methylation
Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.	1995	262	Folate and B Vitamins Research
Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate	1990	117	Colorectal Cancer Treatments and Studies
Determination of rates and yields of interchromophore (folate .fwdarw. flavin) energy transfer and intermolecular (flavin .fwdarw. DNA) electron transfer in Escherichia coli photolyase by time-resolved fluorescence and absorption spectroscopy	1991	112	Photosynthetic Processes and Mechanisms

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of 5,10-Methylene-5,6,7,8-tetrahydrofolic acid?

5,10-Methylene-5,6,7,8-tetrahydrofolic acid has a molecular formula of C20H23N7O6 and a molecular weight of 457.447.

Which organizations hold the most patents related to this compound?

The leading patent assignees for this compound are Danisco US Inc with 144 patents, Goodyear Tire and Rubber Co with 92 patents, and BASF SE with 83 patents.

What research topics are associated with publications on this compound?

Publications on this compound are associated with Folate and B Vitamins Research, Amino Acid Enzymes and Metabolism, Cancer Research and Treatments, Enzyme Structure and Function, and Neuroscience and Neuropharmacology Research.

What is a highly-cited paper on the mechanisms involving 5,10-methylenetetrahydrofolate?

A key paper is the 1990 publication on the stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate, which received 117 citations.

What are the major patent classification areas for inventions involving this compound?

The largest patent classification areas are A61K (687 patents), A61P (661 patents), C12N (648 patents), and C12P (580 patents), reflecting pharmaceutical, biotech, and chemical processing applications.