5,10-Methylene-5,6,7,8-tetrahydrofolic acid - patents, research & applications

1,933Patents

223Research papers

275Patents - last 3 years

2Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#	Assignee	Patents
1	International Flavors and Fragrances Inc	145
2	Goodyear Tire and Rubber Co	92
3	BASF SE	83
4	Merck KGaA	75
5	Corteva Inc	67

6	AbbVie Inc	50
7	Evonik Industries AG	35
8	McGill University	16
9	Viracta Therapeutics Inc	12
10	Montana Tech Components AG	11

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#	Code	Area	Patents
1	`A61K`	Medicinal preparations	687
2	`A61P`	Therapeutic activity (drug indications)	661
3	`C12N`	Microorganisms, enzymes	648
4	`C12P`	Fermentation, enzyme processes	580
5	`C07D`	Heterocyclic compounds	279

6	`C12Y`	Enzyme nomenclature (EC numbers)	277
7	`C12Q`	Measuring/testing involving enzymes	268
8	`C07K`	Peptides	210
9	`G01N`	Investigating / analysing materials	202
10	`Y02E`	Climate change mitigation: energy	192

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

Title	Year	Assignee	Cited by
Aptamers specific for biomolecules and methods of making	1998	Gilead Sciences Inc	452
MODIFIED POLYNUCLEOTIDES FOR THE PRODUCTION OF CYTOPLASMIC AND CYTOSKELETAL PROTEINS	2013	Moderna Inc	196
Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism	1997	Corteva Inc	408
Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases	2005	CareDx Inc	265
COMPOSITIONS AND METHODS FOR PRODUCING ISOPRENE	2009	International Flavors and Fragrances Inc	173

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

Year	Papers
2016	5
2017	1
2018	3
2019	4
2020	4
2021	1
2023	1
2024	1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#	Author	Affiliation	Papers
1	R. Bruce Dunlap	University of South Carolina	9
2	David G. Priest	Medical University of South Carolina	9
3	Daniel V. Santi	University of California, San Francisco	8
4	Amnon Kohen	University of Iowa	6
5	Rowena G. Matthews	University of Michigan	6

6	Robert M. Stroud	University of California, San Francisco	5
7	M.T. Doig	Medical University of South Carolina	5
8	Zhenggang Zhang	Roswell Park Comprehensive Cancer Center	4
9	Wojciech Rode	Instytut Biologii Doświadczalnej im. Marcelego Nenckiego	4
10	Janet Finer-Moore	University of California, San Francisco	4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Title	Year	Cited by	Topic
A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase	1995	5722	Folate and B Vitamins Research
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.	1997	794	Epigenetics and DNA Methylation
Seven novel mutations in the methylenetetrahydrofolate reductase gene and genotype/phenotype correlations in severe methylenetetrahydrofolate reductase deficiency.	1995	262	Folate and B Vitamins Research
Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2′-deoxyuridylate and 5,10-methylenetetrahydrofolate	1990	117	Colorectal Cancer Treatments and Studies
Determination of rates and yields of interchromophore (folate .fwdarw. flavin) energy transfer and intermolecular (flavin .fwdarw. DNA) electron transfer in Escherichia coli photolyase by time-resolved fluorescence and absorption spectroscopy	1991	112	Photosynthetic Processes and Mechanisms

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of 5,10-Methylene-5,6,7,8-tetrahydrofolic acid?

5,10-Methylene-5,6,7,8-tetrahydrofolic acid has the molecular formula C20H23N7O6 and a molecular weight of 457.447.

Which organizations hold the most patents involving this compound?

International Flavors and Fragrances Inc holds the most patents (145), followed by Goodyear Tire and Rubber Co (92), BASF SE (83), Merck KGaA (75), and Corteva Inc (67).

What research topics are most commonly associated with published papers on this compound?

Research topics include Folate and B Vitamins Research, Epigenetics and DNA Methylation, Colorectal Cancer Treatments and Studies, and Photosynthetic Processes and Mechanisms, as shown in papers such as those studying methylenetetrahydrofolate reductase polymorphism and thymidylate synthase mechanisms.

How has patent activity for this compound changed in recent years?

Patent activity has grown significantly, with 47 patents filed in 2016, increasing to 146 in 2023 and 141 in 2024. Over the last 3 years, 275 patents have been filed involving this compound.

Which research groups have published the most papers on this compound?

R. Bruce Dunlap (University of South Carolina) and David G. Priest (Medical University of South Carolina) have each authored 9 papers, followed by Daniel V. Santi (University of California, San Francisco) with 8 papers, and Amnon Kohen (University of Iowa) and Rowena G. Matthews (University of Michigan) with 6 papers each.