25,848 patents · 31,835 papers · 3,007 patents and 1,325 papers in the last 3 years.
Top assignees
- Procter and Gamble Co (312 patents)
- Henkel AG and Co KGaA (282 patents)
- Kao Corp (238 patents)
Notable patents
- High-affinity nucleic acid ligands that discriminate between theophylline and caffeine (1996)
- Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine (2019)
- Method for oral spray administration of caffeine (1995)
Notable papers
Top assignees
| Assignee | Patents |
|---|---|
| Procter and Gamble Co | 312 |
| Henkel AG and Co KGaA | 282 |
| Kao Corp | 238 |
| Beiersdorf AG | 207 |
| LOreal SA | 162 |
| Suntory Holdings Ltd | 157 |
| General Foods Corp | 124 |
| Societe des Produits Nestle SA | 121 |
| Coca Cola Co | 107 |
| Nestec SA | 101 |
Top authors
| Author | Affiliation | Papers |
|---|---|---|
| Juan Del Coso | Universidad Rey Juan Carlos | 46 |
| Bertil B. Fredholm | Karolinska Institutet | 39 |
| Donald M. Bers | Loyola University Chicago | 28 |
| Andrew Smith | Cardiff University | 24 |
| Jiang‐Fan Chen | Boston University | 22 |
| Hui Wang | Wuhan University | 21 |
| B.A. Kihlman | Uppsala University | 20 |
| David Eisner | University of Liverpool | 19 |
| Fabrice Gritti | University of Tennessee at Knoxville | 19 |
| Christa E. Müller | University of Bonn | 17 |
Top patents
| Title | Year | Assignee | Citations |
|---|---|---|---|
| High-affinity nucleic acid ligands that discriminate between theophylline and caffeine | 1996 | Gilead Sciences Inc | 496 |
| Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine | 2019 | General Hospital Corp | 353 |
| Method for oral spray administration of caffeine | 1995 | SPECTOR; JOHN E. | 127 |
| Herbal caffeine replacement composition and food products incorporating same | 2002 | ZHOU JAMES H. | 72 |
| Composition comprising caffeine chromium and fructose for weight control and use thereof | 1996 | ALLEN; ANN DE WEES T. | 72 |
Top papers
| Title | Year | Citations | Topic |
|---|---|---|---|
| Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration | 2007 | 8377 | Meta-analysis and systematic reviews |
| Participation of p53 protein in the cellular response to DNA damage. | 1991 | 3800 | Cancer-related Molecular Pathways |
| Risk Factors for Hip Fracture in White Women | 1995 | 3584 | Bone health and osteoporosis research |
| Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use | 1999 | 2604 | Neuroscience and Neuropharmacology Research |
| Social Jetlag: Misalignment of Biological and Social Time | 2006 | 2549 | Sleep and related disorders |
Patent classifications
| Code | Area | Patents |
|---|---|---|
A61K | Medicinal preparations | 11,261 |
A61P | Therapeutic activity (drug indications) | 7,120 |
A23L | Foods and beverages (general) | 4,029 |
A61Q | Cosmetics, personal care | 3,575 |
A23F | Coffee, tea; their substitutes | 3,114 |
A23V | Foods, foodstuffs - indexing scheme | 2,702 |
C07D | Heterocyclic compounds | 1,759 |
G01N | Investigating / analysing materials | 1,276 |
A23G | Cocoa, chocolate, confectionery | 963 |
C12N | Microorganisms, enzymes | 878 |
Research topics
| Topic | Papers |
|---|---|
| Coffee research and impacts | 66 |
| Ion channel regulation and function | 47 |
| Adenosine and Purinergic Signaling | 23 |
| Neuroscience and Neuropharmacology Research | 19 |
| Cardiac electrophysiology and arrhythmias | 17 |
| Migraine and Headache Studies | 13 |
| Muscle metabolism and nutrition | 12 |
| Diet and metabolism studies | 11 |
| Neonatal Respiratory Health Research | 11 |
| Pharmacogenetics and Drug Metabolism | 11 |
Frequently asked questions
What is the chemical composition and molecular formula of caffeine?
Caffeine has the molecular formula C8H10N4O2 with a molecular weight of 194.194. Its canonical chemical name is 1,3,7-trimethylpurine-2,6-dione, and it is also known by several synonyms including Thein, Theine, and Kofein.
Which organizations hold the most patents related to caffeine?
Procter and Gamble Co leads with 312 patents, followed by Henkel AG and Co KGaA with 282 patents, and Kao Corp with 238 patents. Other major patent holders include Beiersdorf AG with 207 patents and LOreal SA with 162 patents.
What are the primary research topics associated with caffeine in scientific literature?
The leading research topics include Coffee research and impacts with 66 papers, Ion channel regulation and function with 47 papers, and Adenosine and Purinergic Signaling with 23 papers. Other significant areas include Neuroscience and Neuropharmacology Research, Cardiac electrophysiology and arrhythmias, and Migraine and Headache Studies.
What are the most cited patents and papers related to caffeine?
The most-cited patent is "High-affinity nucleic acid ligands that discriminate between theophylline and caffeine" from 1996 with 496 citations. The most-cited paper is "Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration" from 2007 with 8,377 citations, followed by "Participation of p53 protein in the cellular response to DNA damage" from 1991 with 3,800 citations.
What patent classification areas dominate caffeine-related inventions?
The most common CPC subclass is A61K with 11,261 patents, followed by A61P with 7,120 patents and A23L with 4,029 patents. Other significant classifications include A61Q with 3,575 patents and A23F with 3,114 patents, reflecting applications in pharmaceutical, food, and cosmetic formulations.