Who owns the IP
The organizations most actively patenting around this compound, ranked by referenced patent volume.
| # | Assignee | Patents |
|---|---|---|
| 1 | Procter and Gamble Co | 331 |
| 2 | Nestle SA | 320 |
| 3 | Henkel AG and Co KGaA | 302 |
| 4 | Kao Corp | 261 |
| 5 | Maxingvest AG | 210 |
| 6 | Mondelez International Inc | 198 |
| 7 | L'Oréal SA | 194 |
| 8 | Suntory Holdings Ltd | 189 |
| 9 | Pfizer Inc | 125 |
| 10 | Unilever PLC | 124 |
Explore the full landscape
This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.
Visit CyprisWhere innovation is concentrated
Patent classifications ranked by volume reveal the technical domains with the most active filing.
| # | Code | Area | Patents |
|---|---|---|---|
| 1 | A61K | Medicinal preparations | 11,274 |
| 2 | A61P | Therapeutic activity (drug indications) | 7,127 |
| 3 | A23L | Foods and beverages (general) | 4,030 |
| 4 | A61Q | Cosmetics, personal care | 3,575 |
| 5 | A23F | Coffee, tea; their substitutes | 3,127 |
| 6 | A23V | Foods, foodstuffs - indexing scheme | 2,702 |
| 7 | C07D | Heterocyclic compounds | 1,759 |
| 8 | G01N | Investigating / analysing materials | 1,274 |
| 9 | A23G | Cocoa, chocolate, confectionery | 960 |
| 10 | C12N | Microorganisms, enzymes | 874 |
AI mapped opportunity space
This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.
See Cypris in actionRepresentative patents
The filings that best characterise the patent activity around this compound, most-referenced first.
| Title | Year | Assignee | Cited by |
|---|---|---|---|
| High-affinity nucleic acid ligands that discriminate between theophylline and caffeine | 1996 | Gilead Sciences Inc | 496 |
| Reversal of general anesthesia by administration of methylphenidate, amphetamine, modafinil, amantadine, and/or caffeine | 2019 | Mass General Brigham Inc | 353 |
| Method for oral spray administration of caffeine | 1995 | 127 | |
| Herbal caffeine replacement composition and food products incorporating same | 2002 | 72 | |
| Composition comprising caffeine chromium and fructose for weight control and use thereof | 1996 | 72 |
How research activity has moved
Papers published per year for this compound, over the last decade of indexed records.
| Year | Papers |
|---|---|
| 2016 | 566 |
| 2017 | 573 |
| 2018 | 606 |
| 2019 | 548 |
| 2020 | 544 |
| 2021 | 513 |
| 2022 | 610 |
| 2023 | 579 |
| 2024 | 568 |
| 2025 | 199 |
Who's driving the science
The most-published authors working with this compound, alongside their primary affiliations.
| # | Author | Affiliation | Papers |
|---|---|---|---|
| 1 | Juan Del Coso | Universidad Rey Juan Carlos | 79 |
| 2 | Donald M. Bers | Loyola University Chicago | 35 |
| 3 | Harris R. Lieberman | U.S. Army Research Institute of Environmental Medicine | 27 |
| 4 | Bertil B. Fredholm | Karolinska Institutet | 25 |
| 5 | David Eisner | University of Liverpool | 24 |
| 6 | Jack E. James | Reykjavík University | 23 |
| 7 | Sergi Ferré | National Institute on Drug Abuse | 18 |
| 8 | Andrew Smith | Cardiff University | 18 |
| 9 | Paul D. Allen | Brigham and Women's Hospital | 18 |
| 10 | Thomas J. Balkin | Walter Reed Army Institute of Research | 18 |
Research leaders
This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.
See Cypris in actionThe literature that defines it
The most-cited papers anchoring the scientific record for this compound.
| Title | Year | Cited by | Topic |
|---|---|---|---|
| Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and Elaboration | 2007 | 8538 | Meta-analysis and systematic reviews |
| Participation of p53 protein in the cellular response to DNA damage. | 1991 | 3801 | Cancer-related Molecular Pathways |
| Risk Factors for Hip Fracture in White Women | 1995 | 3593 | Bone health and osteoporosis research |
| Actions of Caffeine in the Brain with Special Reference to Factors That Contribute to Its Widespread Use | 1999 | 2621 | Neuroscience and Neuropharmacology Research |
| Social Jetlag: Misalignment of Biological and Social Time | 2006 | 2619 | Sleep and related disorders |
Frequently asked questions
Common questions about this compound's patent and research landscape, answered from the underlying data.
What is the chemical composition and molecular weight of caffeine?
Which companies hold the most patents related to caffeine?
How much research activity has there been on caffeine in recent years?
What are the main patent classification areas for caffeine-related inventions?
Who are the most prolific authors publishing research on caffeine?