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Branosyn

2-[4-[[(2R)-3,4-dihydro-2H-chromen-2-yl]methylamino]butyl]-1,1-dioxo-1,2-benzothiazol-3-one;hydrochloride · also: Repinotan, Repinotan HCl, RepinotanHydrochloride, Repinotan hydrochloride

FormulaC21H25ClN2O4S
Mol. weight436.951
PubChem CID198756
InChIKeyIGKYREHZJIHPML-UNTBIKODSA-N
SMILESC1CC2=CC=CC=C2O[C@H]1CNCCCCN3C(=O)C4=CC=CC=C4S3(=O)=O.Cl
125Patents
36Research papers
2Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Ascendis Pharma AS23
2Bayer AG22
3H Lundbeck AS20
4Alcon Inc15
5Otsuka Pharmaceutical Co Ltd9
6Ono Pharmaceutical Co Ltd4
7Novartis AG2
8GlaxoSmithKline Intellectual Property No 2 Ltd1

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations103
2A61PTherapeutic activity (drug indications)102
3C07DHeterocyclic compounds57
4Y02PClimate change mitigation: production24
5Y10TCross-reference (technical subjects)23
6G01NInvestigating / analysing materials17
7C08JWorking-up of plastics7
8C07KPeptides6
9A61MDevices for introducing media into the body1
10C12QMeasuring/testing involving enzymes1

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Repinotan kit2003Bayer AG62
REPINOTAN KIT2003Bayer AG1
Specific monoclonal and polyclonal antibodies to repinotan and its ring-open form2005Bayer AG0
Repinotan kit2004Bayer AG0
Repinotan kit2003BAYER AKTIENGESELLSCHAFT0

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Francesc ArtigasInstitut d'Investigacions Biomèdiques de Barcelona6
2Josef KrieglsteinPhilipps University of Marburg5
3Christine SchaperPhilipps University of Marburg4
4Frank MaulerBayer (Germany)4
5Georg WensingBayer (Germany)3
6Irina SemkovaPhilipps University of Marburg3
7Lorenzo Díaz-MataixConsorci Institut D'Investigacions Biomediques August Pi I Sunyer3
8Michael BöettcherBayer (Germany)3
9Pau CeladaConsorci Institut D'Investigacions Biomediques August Pi I Sunyer3
10Albert AdellInstitut d'Investigacions Biomèdiques de Barcelona2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Branosyn?

Branosyn has the molecular formula C21H25ClN2O4S with a molecular weight of 436.951. Its canonical chemical name is 2-[4-[[(2R)-3,4-dihydro-2H-chromen-2-yl]methylamino]butyl]-1,1-dioxo-1,2-benzothiazol-3-one;hydrochloride, and it is also known by the synonym Repinotan hydrochloride.

Which companies hold the most patents for Branosyn?

The leading patent assignees for Branosyn are Ascendis Pharma AS with 23 patents, Bayer AG with 22 patents, and H Lundbeck AS with 20 patents. Together, these three assignees account for a substantial portion of the total 125 patents in the portfolio.

What are the primary research topics associated with Branosyn?

Published research on Branosyn covers several key areas. Notable topics include Neurotransmitter Receptor Influence on Behavior, Cardiac Arrest and Resuscitation, Protein Kinase Regulation and GTPase Signaling, Parkinson's Disease Mechanisms and Treatments, and Neuropeptides and Animal Physiology. A 2001 paper demonstrates that the selective 5-HT1A receptor agonist repinotan HCl attenuates histopathology and spatial learning deficits following traumatic brain injury in rats, and a 2006 paper shows 5-HT1A receptor agonist-mediated protection from MPTP toxicity in Parkinson's disease models.

What are the dominant patent classification codes for Branosyn intellectual property?

The most frequently used CPC patent classification codes for Branosyn are A61K (103 patents) and A61P (102 patents), which relate to medicinal and pharmaceutical preparations and therapeutic applications respectively. Additional significant classifications include C07D (57 patents) for organic chemistry and heterocyclic compounds, Y02P (24 patents) for climate change mitigation technologies, and Y10T (23 patents) for technical subjects.

Who are the leading researchers publishing on Branosyn?

The most prolific authors in Branosyn research include Francesc Artigas from Institut d'Investigacions Biomèdiques de Barcelona with 6 papers, Josef Krieglstein from Philipps University of Marburg with 5 papers, and Christine Schaper also from Philipps University of Marburg with 4 papers. Researchers from Bayer (Germany) including Frank Mauler and Michael Böettcher have also contributed significantly to the literature.

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