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Repinotan hydrochloride

2-[4-[[(2R)-3,4-dihydro-2H-chromen-2-yl]methylamino]butyl]-1,1-dioxo-1,2-benzothiazol-3-one;hydrochloride · also: Branosyn · Bay-x-3702 · Bay x 3702 · Repinotan HCl · RepinotanHydrochloride · Repinotan (hydrochloride)

FormulaC21H25ClN2O4S
Mol. weight436.951
PubChem CID198756
InChIKeyIGKYREHZJIHPML-UNTBIKODSA-N
SMILESC1CC2=CC=CC=C2O[C@H]1CNCCCCN3C(=O)C4=CC=CC=C4S3(=O)=O.Cl
125Patents
36Research papers
2Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Ascendis Pharma AS23
2Bayer AG22
3H Lundbeck AS20
4Alcon Inc15
5Otsuka Holdings Co Ltd9
6Ono Pharmaceutical Co Ltd4
7Novartis AG2
8GSK PLC1

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations103
2A61PTherapeutic activity (drug indications)102
3C07DHeterocyclic compounds57
4Y02PClimate change mitigation: production24
5Y10TCross-reference (technical subjects)23
6G01NInvestigating / analysing materials17
7C08JWorking-up of plastics7
8C07KPeptides6
9A61MDevices for introducing media into the body1
10C12QMeasuring/testing involving enzymes1

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
DIPEPTIDE-BASED PRODRUG LINKERS FOR ALIPHATIC AMINE-CONTAINING DRUGS2011Ascendis Pharma AS179
BIODEGRADABLE POLYETHYLENE GLYCOL BASED WATER-INSOLUBLE HYDROGELS2011Ascendis Pharma AS176
1- [2- (2, 4-DIMETHYLPHENYLSULFANYL) -PHENYL] PIPERAZINE AS A COMPOUND WITH COMBINED SEROTONIN REUPTAKE, 5-HT3 AND 5-HT1A ACTIVITY FOR THE TREATMENT OF COGNITIVE IMPAIRMENT2007H Lundbeck AS161
POLYMERIC HYPERBRANCHED CARRIER-LINKED PRODRUGS2013Ascendis Pharma AS89
PROTEIN CARRIER-LINKED PRODRUGS2013Ascendis Pharma AS78

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Francesc ArtigasInstitut d'Investigacions Biomèdiques de Barcelona6
2Frank MaulerBayer (Germany)4
3Josef KrieglsteinPhilipps University of Marburg4
4Christine SchaperPhilipps University of Marburg4
5Irina SemkovaPhilipps University of Marburg3
6Pau CeladaConsorci Institut D'Investigacions Biomediques August Pi I Sunyer3
7Lorenzo Díaz-MataixInstitut d'Investigacions Biomèdiques de Barcelona3
8Michael BöettcherBayer (Germany)3
9Georg WensingBayer (Germany)3
10Barbara AhlemeyerPhilipps University of Marburg2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of Repinotan hydrochloride?

Repinotan hydrochloride has the molecular formula C21H25ClN2O4S and a molecular weight of 436.951. Its canonical IUPAC name is 2-[4-[[(2R)-3,4-dihydro-2H-chromen-2-yl]methylamino]butyl]-1,1-dioxo-1,2-benzothiazol-3-one;hydrochloride.

Which organizations hold the most patents for Repinotan hydrochloride?

Ascendis Pharma AS holds the most patents with 23, followed by Bayer AG with 22 and H Lundbeck AS with 20 patents related to this compound.

What is the current patent activity trend for Repinotan hydrochloride?

Patent activity has been low in recent years, with 2 patents filed in the last 3 years (2023–2025). Historical peaks occurred in 2016 and 2017, each with 4 patents. The total patent portfolio encompasses 125 patents across the full historical record.

What are the primary research topics associated with Repinotan hydrochloride?

Research on Repinotan hydrochloride focuses on its mechanism as a 5-HT1A receptor agonist and its therapeutic applications. Key topics include neuroprotection in traumatic brain injury, Parkinson's disease treatment, and neurotransmitter receptor signaling pathways including G protein-coupled receptor mechanisms and protein kinase regulation.

Who are the leading authors publishing on Repinotan hydrochloride?

Francesc Artigas from Institut d'Investigacions Biomèdiques de Barcelona is the most prolific author with 6 papers. Other leading contributors include Frank Mauler from Bayer (Germany), Josef Krieglstein and Christine Schaper from Philipps University of Marburg, each with 4 papers on the compound.

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