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Boscalid metabolite

2-chloropyridine-3-carboxylic acid · also: chloronicotinic acid, Flunixin EP Impurity A, Niflumic acid impurity A, Flunixin Related Compound A, Niflumic acid impurity A CRS

FormulaC6H4ClNO2
Mol. weight157.553
PubChem CID76258
InChIKeyIBRSSZOHCGUTHI-UHFFFAOYSA-N
SMILESC1=CC(=C(N=C1)Cl)C(=O)O
3,964Patents
21Research papers
260Patents - last 3 years
1Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1F Hoffmann La Roche AG151
2Pfizer Inc123
3Amgen Inc87
4Pfizer Corp SRL84
5Boehringer Ingelheim Pharmaceuticals Inc65
6Takeda Pharmaceutical Co Ltd59
7Pfizer Corp Belgium49
8Eli Lilly and Co45
9Abbott Laboratories42
10AstraZeneca AB40

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C07DHeterocyclic compounds3,258
2A61PTherapeutic activity (drug indications)2,548
3A61KMedicinal preparations1,264
4C07CAcyclic and carbocyclic compounds484
5A01NPreservation of bodies; biocides; pest repellents262
6Y02AClimate change adaptation158
7C07FOrganometallic compounds151
8C07BGeneral methods of organic chemistry108
9Y02PClimate change mitigation: production98
10C07KPeptides88

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Preparation method of 2-chloronicotinic acid2008Zhejiang Medicine Co Ltd23
PREPARATION OF 2-CHLORONICOTINIC ACID1984YUKI GOSEI YAKUHIN KOGYO KK10
Nitrilase mutant and application thereof in catalytic synthesis of 2-chloronicotinic acid2020Zhejiang University of Technology9
Process for the production of pure white 2-chloronicotinic acid1979Lonza AG8
Synthesis method of 2-chloronicotinic acid and derivative thereof2013Zhejiang University of Technology7

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Bruce S. EdwardsUniversity of New Mexico3
2Islam Ullah KhanGovernment College University, Lahore3
3Larry A. SklarUniversity of New Mexico3
4Matthew SaundersUniversity of New Mexico3
5Misbahul Ain KhanIslamia University of Bahawalpur3
6Muhammad Nadeem ArshadGovernment College University, Lahore3
7Muhammad Naeem KhanIslamia University of Bahawalpur3
8Steven W. GravesLos Alamos National Laboratory3
9Anton SimeonovNational Center for Advancing Translational Sciences2
10Muhammad Nawaz TahirUniversity of Sargodha2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical identity of this compound?

2-chloropyridine-3-carboxylic acid is a compound with the molecular formula C6H4ClNO2 and a molecular weight of 157.553. It is also known by several alternative names including chloronicotinic acid, Flunixin EP Impurity A, Niflumic acid impurity A, Flunixin Related Compound A, and Niflumic acid impurity A CRS. The compound has an InChI Key of IBRSSZOHCGUTHI-UHFFFAOYSA-N.

Which organizations hold the most patents related to this compound?

F Hoffmann La Roche AG leads with 151 patents, followed by Pfizer Inc with 123 patents and Amgen Inc with 87 patents. Other significant patent holders include Pfizer Corp SRL (84 patents), Boehringer Ingelheim Pharmaceuticals Inc (65 patents), and Takeda Pharmaceutical Co Ltd (59 patents).

What patent technologies are most commonly associated with this compound?

The dominant patent classification is C07D (covering heterocyclic compounds), which appears in 3258 patents. This is followed by A61P (specific therapeutic activity of chemical compounds, 2548 patents) and A61K (preparations for medical or veterinary use, 1263 patents). C07C (acyclic or carbocyclic compounds, 484 patents) and A01N (pesticides, 262 patents) also represent significant areas of patent activity.

What scientific research has been published on related compounds?

Research on structurally related compounds includes a study on 2-Bromopyridine-3-carboxylic acid focusing on metal complexes synthesis and properties (84 citations), and a study characterizing a bacterial strain (Rhodococcus erythropolis ZJB-09149) that transforms 2-chloro-3-cyanopyridine to 2-chloronicotinic acid in the context of enzyme catalysis and immobilization (19 citations). Additional work has examined synthesis and biological activity of related heterocyclic compounds.

How has patent activity for this compound trended in recent years?

Patent filings related to this compound showed growth from 2016 (94 patents) through a peak in 2022 (151 patents), followed by a decline to 115 patents in 2024. Over the last 3 years (2022–2024), 385 patents were filed. In contrast, scientific paper output has been minimal, with only 1 paper published in each of 2020, 2022, and 2023.

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