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Bixin

(2E,4E,6E,8E,10E,12E,14E,16Z,18E)-20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid · also: Bixinol, a-Bixin, Isobixin, cis-Bixin, alpha-Bixin, Stable bixin

FormulaC25H30O4
Mol. weight394.511
PubChem CID5281226
InChIKeyRAFGELQLHMBRHD-SLEZCNMESA-N
SMILESC/C(=C\C=C\C=C(/C)\C=C\C=C(\C)/C=C/C(=O)OC)/C=C/C=C(\C)/C=C/C(=O)O
4,033Patents
120Research papers
268Patents - last 3 years
13Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Intercontinental Great Brands LLC300
2BASF SE272
3DSM IP Assets BV93
4Fujifilm Corp86
5Nissan Chemical Corp61
6Nippon Fine Chemical Co Ltd59
7Mars Petcare US Inc53
8Beiersdorf AG48
9Amyris Inc47
10Mars Inc46

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations1,803
2A23LFoods and beverages (general)1,098
3A61QCosmetics, personal care980
4A61PTherapeutic activity (drug indications)939
5A23VFoods, foodstuffs - indexing scheme704
6A23GCocoa, chocolate, confectionery598
7A23KAnimal feeds446
8A23P336
9C09B221
10C07CAcyclic and carbocyclic compounds202

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Bixin colorant compositions2000Viskase Companies LLC37
BIXIN DERIVATIVE AND CYTOPROTECTIVE AGENT2012GIFU CITY6
Carotenoid dye esp. lycopene prepn. - by esterifying bixin, reducing ester and reacting alcohol with ketone esp. methyl heptenone1977FRIEDRICH KARL MARCUS CHEM FAB6
Process to convert bixin to a food color and the resulting product1957KEYSTONE CHEMURGIC CORPORATION4
Novel esters of bixins and norbixins and process for the manufacture thereof1956Roche Products Ltd3

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Biological Stains and Phytochemicals1
2Free Radicals and Antioxidants1
3Genetics, Aging, and Longevity in Model Organisms1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Sankari MohanVellore Institute of Technology University4
2Alessandro de Oliveira RiosUniversidade Federal do Rio Grande do Sul5
3C. George Priya DossVellore Institute of Technology University5
4Hridya HemachandranVellore Institute of Technology University5
5Lusânia Maria Greggi AntunesUniversidade de São Paulo5
6Shasha TaoSoochow University5
7Renata Rivera‐MadridSecretaría de Investigación, Innovación y Educación Superior4
8Siva RamamoorthyVellore Institute of Technology University4
9Adriana Zerlotti MercadanteUniversidade Estadual de Campinas (UNICAMP)3
10Daniele Vidal FariaUniversidade Federal de Viçosa3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of bixin?

Bixin has the molecular formula C25H30O4 with a molecular weight of 394.511. Its canonical IUPAC name is (2E,4E,6E,8E,10E,12E,14E,16Z,18E)-20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid.

Which companies hold the most patents involving bixin?

Intercontinental Great Brands LLC leads with 300 patents, followed by BASF SE with 272 patents and DSM IP Assets BV with 93 patents. Other significant patent holders include Fujifilm Corp, Nissan Chemical Corp, Nippon Fine Chemical Co Ltd, Mars Petcare US Inc, Beiersdorf AG, Amyris Inc, and Mars Inc.

What are the primary patent classification areas for bixin technologies?

The largest patent classification area is A61K (pharmaceutical preparations) with 1803 patents, followed by A23L (food compositions) with 1098 patents and A61Q (cosmetics) with 980 patents. Additional significant classifications include A61P (medical use preparation), A23V (animal feeding stuffs), and A23G (chocolate and confectionery).

What notable research has been published on bixin's biological properties?

High-impact papers include a 2003 study on the biosynthesis of bixin in annatto plants with 249 citations, a 2011 paper on complexation of bixin with β-cyclodextrin with 179 citations, and a 2001 study demonstrating antioxidant action of bixin against cisplatin-induced damage with 123 citations. Research has also covered biochemistry of annatto (126 citations) and protein-bixin binding interactions (118 citations).

How has patent activity for bixin evolved in recent years?

Patent filings for bixin showed relatively consistent activity from 2016 to 2023, with annual counts ranging from 129 to 178 patents. The year 2021 saw the highest activity at 178 patents. Data for 2024 shows 141 patents and 2025 shows only 6 patents, though 2025 data is incomplete. Academic paper publication has remained stable at 5-9 papers annually from 2016 to 2023.

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