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Bixin

(2E,4E,6E,8E,10E,12E,14E,16Z,18E)-20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid · also: a-Bixin, Isobixin, cis-Bixin, alpha-Bixin, Stable bixin, Annatto (E 160b)

FormulaC25H30O4
Mol. weight394.511
PubChem CID5281226
InChIKeyRAFGELQLHMBRHD-SLEZCNMESA-N
SMILESC/C(=C\C=C\C=C(/C)\C=C\C=C(\C)/C=C/C(=O)OC)/C=C/C=C(\C)/C=C/C(=O)O
4,033Patents
120Research papers
257Patents - last 3 years
13Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Intercontinental Great Brands LLC300
2BASF SE272
3DSM IP Assets BV93
4Fujifilm Corp86
5Nissan Chemical Corp61
6Nippon Fine Chemical Co Ltd59
7Mars Petcare US Inc53
8Beiersdorf AG48
9Amyris Inc47
10Mars Inc46

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations1,803
2A23LFoods and beverages (general)1,098
3A61QCosmetics, personal care980
4A61PTherapeutic activity (drug indications)939
5A23VFoods, foodstuffs - indexing scheme704
6A23GCocoa, chocolate, confectionery598
7A23KAnimal feeds446
8A23P336
9C09B221
10C07CAcyclic and carbocyclic compounds202

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Bixin colorant compositions2000Viskase Companies LLC37
BIXIN DERIVATIVE AND CYTOPROTECTIVE AGENT2012GIFU CITY6
Carotenoid dye esp. lycopene prepn. - by esterifying bixin, reducing ester and reacting alcohol with ketone esp. methyl heptenone1977FRIEDRICH KARL MARCUS CHEM FAB6
Process to convert bixin to a food color and the resulting product1957KEYSTONE CHEMURGIC CORPORATION4
Novel esters of bixins and norbixins and process for the manufacture thereof1956Roche Products Ltd3

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Antioxidant Activity and Oxidative Stress1
2Biological Stains and Phytochemicals1
3Free Radicals and Antioxidants1
4Genetics, Aging, and Longevity in Model Organisms1
5Genomics, phytochemicals, and oxidative stress1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Sankari MohanVellore Institute of Technology University4
2Alessandro de Oliveira RiosUniversidade Federal do Rio Grande do Sul5
3C. George Priya DossVellore Institute of Technology University5
4Hridya HemachandranVellore Institute of Technology University5
5Lusânia Maria Greggi AntunesUniversidade de São Paulo5
6Shasha TaoSoochow University5
7Renata Rivera‐MadridSecretaría de Investigación, Innovación y Educación Superior4
8Siva RamamoorthyVellore Institute of Technology University4
9Adriana Zerlotti MercadanteUniversidade Estadual de Campinas (UNICAMP)3
10Daniele Vidal FariaUniversidade Federal de Viçosa3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of bixin?

Bixin has the molecular formula C25H30O4 with a molecular weight of 394.511 g/mol. Its canonical IUPAC name is (2E,4E,6E,8E,10E,12E,14E,16Z,18E)-20-methoxy-4,8,13,17-tetramethyl-20-oxoicosa-2,4,6,8,10,12,14,16,18-nonaenoic acid.

Which companies hold the most patents involving bixin?

The leading patent assignees for bixin-related inventions are Intercontinental Great Brands LLC with 300 patents, BASF SE with 272 patents, and DSM IP Assets BV with 93 patents.

What are the primary application areas for bixin based on patent classification?

The largest patent classification areas for bixin are pharmaceuticals and cosmetics (A61K with 1803 patents), food additives and colorants (A23L with 1098 patents), and cosmetic preparations (A61Q with 980 patents). These dominate the patent landscape for this compound.

What research topics have been published on bixin in recent peer-reviewed literature?

Published research on bixin spans biosynthesis and photosynthetic processes, antioxidant activity and oxidative stress, interactions with food proteins and cyclodextrins, and biological applications as a phytochemical. Key papers include work on biosynthesis of the food and cosmetic plant pigment bixin, antioxidant action against cisplatin-induced damage, and binding interactions with whey protein.

How has patent activity for bixin changed in recent years?

Patent activity for bixin shows sustained interest, with 257 patents filed in the last 3 years. Annual patent filings ranged from 129 patents in 2019 to 178 in 2021, though 2024 and 2025 show lower counts (141 and 51 patents respectively). Scientific publications have remained relatively stable, with 13 papers published in the last 3 years.

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