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Ara C

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one · also: Ara-C, Iretin, Udicil, Alexan, Depocyt, Arabine

FormulaC9H13N3O5
Mol. weight243.219
PubChem CID6253
InChIKeyUHDGCWIWMRVCDJ-CCXZUQQUSA-N
SMILESC1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O
20,764Patents
17,917Research papers
2,100Patents - last 3 years
471Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck Sharp and Dohme LLC529
2Immunomedics Inc262
3Bayer Intellectual Property GmbH172
4Bristol Myers Squibb Co163
5Bayer Pharma AG149
6Genentech Inc137
7Centre National de la Recherche Scientifique CNRS133
8Vertex Pharmaceuticals Inc109
9Celgene Corp107
10Novartis AG103

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)16,953
2A61KMedicinal preparations16,930
3C07DHeterocyclic compounds5,588
4C07KPeptides4,993
5C12NMicroorganisms, enzymes2,371
6G01NInvestigating / analysing materials1,690
7Y02AClimate change adaptation1,430
8C07HSugars and derivatives1,028
9C12QMeasuring/testing involving enzymes929
10C07FOrganometallic compounds798

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Polymer conjugates of ara-C and ara-C derivatives2002Enzon Pharmaceuticals Inc56
Polymer conjugates of ara-C and ara-C derivatives2003エンゾン,インコーポレーテッド26
POLYMER CONJUGATES OF ARA-C AND ARA-C DERIVATIVES2001Enzon Pharmaceuticals Inc14
Alexan 5'-O-amino acid ester hydrochloride and preparation method thereof2008SHENYANG PHARMACEUTICAL UNIVERSITY10
Pharmaceutical composition containing 5'-Ara-C-O-amino ester2016KUNMING JIDA PHARMACEUTICAL CO., LTD.4

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Acute Myeloid Leukemia Research128
2Acute Lymphoblastic Leukemia research42
3Lymphoma Diagnosis and Treatment30
4CNS Lymphoma Diagnosis and Treatment14
5Neutropenia and Cancer Infections14
6Retinoids in leukemia and cellular processes14
7Chronic Myeloid Leukemia Treatments12
8Chronic Lymphocytic Leukemia Research11
9Hematopoietic Stem Cell Transplantation11
10Biochemical and Molecular Research10

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Hagop M. KantarjianThe University of Texas MD Anderson Cancer Center230
2Elihu H. EsteyThe University of Texas MD Anderson Cancer Center131
3Jörge E. CortesThe University of Texas MD Anderson Cancer Center122
4Wolfgang HiddemannLudwig-Maximilians-Universität München79
5Farhad RavandiThe University of Texas MD Anderson Cancer Center77
6Guillermo Garcia‐ManeroThe University of Texas MD Anderson Cancer Center76
7Susan O’BrienThe University of Texas MD Anderson Cancer Center75
8Michael J. KeatingThe University of Texas MD Anderson Cancer Center70
9Franco MandelliSapienza University of Rome51
10Richard A. LarsonUniversity of Chicago49

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Ara C?

Ara C has the molecular formula C9H13N3O5 and a molecular weight of 243.219 g/mol. Its canonical IUPAC name is 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one.

Which organizations have the largest patent portfolios related to Ara C?

The leading patent assignees for Ara C-related inventions are Merck Sharp and Dohme LLC with 529 patents, Immunomedics Inc with 262 patents, and Bayer Intellectual Property GmbH with 172 patents. Other significant assignees include Bristol Myers Squibb Co, Bayer Pharma AG, and Genentech Inc.

What are the primary research areas associated with Ara C?

The dominant research topic is Acute Myeloid Leukemia Research with 128 papers, followed by Acute Lymphoblastic Leukemia research with 42 papers. Other significant research areas include Lymphoma Diagnosis and Treatment, Chronic Myeloid Leukemia Treatments, and Hematopoietic Stem Cell Transplantation.

What polymer conjugate patents have been filed for Ara C?

Key patents on polymer conjugates of Ara-C and Ara-C derivatives include US-6376470-B1 filed in 2002 and CA-2383240-A1 filed in 2001, both assigned to Enzon Pharmaceuticals Inc. A Japanese patent JP-2003524028-A was also filed in 2003 on the same subject matter.

How has publication and patenting activity around Ara C trended in recent years?

Patent activity for Ara C peaked in 2022 with 1,132 patents and has remained between 900–1,100 annually from 2016–2024. Paper publications have declined from a peak of 302 in 2020 to 184 in 2024. Over the last three years, there have been 2,100 patents and 471 papers filed or published.

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