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Cytarabine

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one · also: Ara C · Ara-C · Udicil · Alexan · Cytonal · Cytosar

FormulaC9H13N3O5
Mol. weight243.219
PubChem CID6253
InChIKeyUHDGCWIWMRVCDJ-CCXZUQQUSA-N
SMILESC1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O
20,764Patents
17,917Research papers17,885 indexed in detail
1,895Patents - last 3 years
475Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck and Co Inc663
2Gilead Sciences Inc423
3Bristol Myers Squibb Co404
4Bayer AG358
5Roche Holding AG248
6Centre National de la Recherche Scientifique160
7The University of Texas System156
8Novartis AG150
9Vertex Pharmaceuticals Inc146
10Institut National de la Santé et de la Recherche Médicale135

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)16,957
2A61KMedicinal preparations16,943
3C07DHeterocyclic compounds5,588
4C07KPeptides5,005
5C12NMicroorganisms, enzymes2,382
6G01NInvestigating / analysing materials1,690
7Y02AClimate change adaptation1,438
8C07HSugars and derivatives1,028
9C12QMeasuring/testing involving enzymes929
10C07FOrganometallic compounds798

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Polymer conjugates of ara-C and ara-C derivatives2002Icahn Enterprises LP56
ANTITUMOR COMBINATIONS CONTAINING ANTIBODIES RECOGNIZING SPECIFICALLY CD38 AND CYTARABINE2010Sanofi SA49
Preparing method for cytarabine200534
VOLASERTIB ALONE OR IN COMBINATION WITH CYTARABINE FOR TREATING ACUTE MYELOID LEUKEMIA2012C.H. Boehringer Sohn AG and Co KG30
Polymer conjugates of ara-C and ara-C derivatives200326

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
2016258
2017250
2018285
2019284
2020303
2021246
2022236
2023207
2024187
202581

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Hagop M. KantarjianThe University of Texas MD Anderson Cancer Center231
2Elihu H. EsteyThe University of Texas MD Anderson Cancer Center132
3Jörge E. CortesThe University of Texas MD Anderson Cancer Center122
4Farhad RavandiThe University of Texas MD Anderson Cancer Center88
5Guillermo Garcia‐ManeroThe University of Texas MD Anderson Cancer Center74
6Wolfgang HiddemannLudwig-Maximilians-Universität München70
7Michael J. KeatingThe University of Texas MD Anderson Cancer Center60
8William PlunkettThe University of Texas MD Anderson Cancer Center53
9Richard A. LarsonUniversity of Chicago49
10Franco MandelliSapienza University of Rome49

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of cytarabine?

Cytarabine has the molecular formula C9H13N3O5 and a molecular weight of 243.219 g/mol.

Which companies hold the most patents related to cytarabine?

The leading patent assignees for cytarabine are Merck and Co Inc with 663 patents, Gilead Sciences Inc with 423 patents, and Bristol Myers Squibb Co with 404 patents.

What are the most prolific research authors in cytarabine studies?

The leading researchers by publication count are Hagop M. Kantarjian with 231 papers, Elihu H. Estey with 132 papers, and Jörge E. Cortes with 122 papers, all affiliated with The University of Texas MD Anderson Cancer Center.

What is the coverage of cytarabine in patent and scientific literature databases?

Cytarabine has substantial coverage with 20,764 total patents and 17,917 papers indexed. In the last three years, there were 1,895 patent filings and 475 papers published.

What therapeutic areas are most represented in cytarabine patent classifications?

The dominant CPC subclasses are A61P (medicinal preparations) with 16,957 patents and A61K (pharmaceutical preparations) with 16,943 patents, indicating cytarabine is primarily classified within therapeutic and pharmaceutical invention categories.

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