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Cytarabine

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one · also: Ara C, Ara-C, Udicil, Alexan, Cytonal, Depocyt

FormulaC9H13N3O5
Mol. weight243.219
PubChem CID6253
InChIKeyUHDGCWIWMRVCDJ-CCXZUQQUSA-N
SMILESC1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](O2)CO)O)O
20,764Patents
17,917Research papers
1,988Patents - last 3 years
475Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck Sharp & Dohme LLC529
2Immunomedics Inc262
3Bayer Intellectual Property GmbH172
4Bristol Myers Squibb Co162
5Bayer Pharma AG150
6Genentech Inc137
7Centre National de la Recherche Scientifique133
8Vertex Pharmaceuticals Inc109
9Celgene Corp106
10Novartis AG103

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61PTherapeutic activity (drug indications)16,955
2A61KMedicinal preparations16,935
3C07DHeterocyclic compounds5,588
4C07KPeptides5,003
5C12NMicroorganisms, enzymes2,375
6G01NInvestigating / analysing materials1,690
7Y02AClimate change adaptation1,430
8C07HSugars and derivatives1,028
9C12QMeasuring/testing involving enzymes929
10C07FOrganometallic compounds798

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Polymer conjugates of ara-C and ara-C derivatives2002Enzon Pharmaceuticals Inc56
ANTITUMOR COMBINATIONS CONTAINING ANTIBODIES RECOGNIZING SPECIFICALLY CD38 AND CYTARABINE2010Sanofi Aventis France49
Preparing method for cytarabine2005ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.34
VOLASERTIB ALONE OR IN COMBINATION WITH CYTARABINE FOR TREATING ACUTE MYELOID LEUKEMIA2012Boehringer Ingelheim International GmbH30
Polymer conjugates of ara-C and ara-C derivatives2003エンゾン,インコーポレーテッド26

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Acute Myeloid Leukemia Research158
2Acute Lymphoblastic Leukemia research51
3Lymphoma Diagnosis and Treatment34
4CNS Lymphoma Diagnosis and Treatment15
5Neutropenia and Cancer Infections15
6Chronic Myeloid Leukemia Treatments14
7Hematopoietic Stem Cell Transplantation14
8Retinoids in leukemia and cellular processes14
9Virus-based gene therapy research13
10Chronic Lymphocytic Leukemia Research12

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Hagop M. KantarjianThe University of Texas MD Anderson Cancer Center231
2Elihu H. EsteyThe University of Texas MD Anderson Cancer Center132
3Jörge E. CortesThe University of Texas MD Anderson Cancer Center122
4Wolfgang HiddemannLudwig-Maximilians-Universität München79
5Farhad RavandiThe University of Texas MD Anderson Cancer Center77
6Guillermo Garcia‐ManeroThe University of Texas MD Anderson Cancer Center76
7Susan O’BrienThe University of Texas MD Anderson Cancer Center75
8Michael J. KeatingThe University of Texas MD Anderson Cancer Center70
9Franco MandelliSapienza University of Rome51
10Richard A. LarsonUniversity of Chicago49

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition and molecular structure of cytarabine?

Cytarabine has the molecular formula C9H13N3O5 with a molecular weight of 243.219. Its canonical chemical name is 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one, and it is also known by the abbreviation Ara-C among numerous other synonyms.

Which organizations hold the most patents related to cytarabine?

The leading patent assignees for cytarabine-related inventions are Merck Sharp & Dohme LLC with 529 patents, Immunomedics Inc with 262 patents, Bayer Intellectual Property GmbH with 172 patents, Bristol Myers Squibb Co with 162 patents, and Bayer Pharma AG with 150 patents.

What are the primary research areas involving cytarabine?

The main research topics associated with cytarabine are Acute Myeloid Leukemia Research with 158 papers, Acute Lymphoblastic Leukemia research with 51 papers, Lymphoma Diagnosis and Treatment with 34 papers, CNS Lymphoma Diagnosis and Treatment with 15 papers, and Neutropenia and Cancer Infections with 15 papers.

How extensive is the patent and publication coverage for cytarabine?

The cytarabine field has substantial intellectual property and scientific activity: a total of 20,764 patents and 17,917 scientific papers are documented in the aggregate. In the last three years, 1,988 patents and 475 papers have been generated, demonstrating continued research and development in this area.

What key patent classifications are associated with cytarabine inventions?

The most common patent classifications for cytarabine-related patents are A61P (pharmaceutical preparations) with 16,955 patents, A61K (medicinal chemistry) with 16,935 patents, C07D (heterocyclic chemistry) with 5,588 patents, and C07K (peptide and protein chemistry) with 5,003 patents, reflecting its pharmaceutical and chemical synthesis applications.

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