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Alecensa

9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;hydrochloride · also: Alectinib, alectinib HCl, Alectinib Hydrochloride, alectinib monohydrochloride

FormulaC30H35ClN4O2
Mol. weight519.086
PubChem CID53239799
InChIKeyGYABBVHSRIHYJR-UHFFFAOYSA-N
SMILESCCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C.Cl
1,147Patents
522Research papers
753Patents - last 3 years
120Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Foundation Medicine Inc84
2Gilead Sciences Inc83
3Chugai Pharmaceutical Co Ltd69
4F Hoffmann La Roche AG28
5Cincinnati Childrens Hospital Medical Center25
6The University of Texas System23
7United States Department of Health and Human Services22
8University of Texas at Austin20
9North Carolina State University17
10Genentech Inc16

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations881
2A61PTherapeutic activity (drug indications)860
3C07KPeptides350
4C07DHeterocyclic compounds320
5C12NMicroorganisms, enzymes196
6C12QMeasuring/testing involving enzymes190
7G16B142
8G01NInvestigating / analysing materials138
9G16HDigital health, healthcare informatics91
10Y02AClimate change adaptation53

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
TREATMENT OF NON SMALL CELL LUNG CANCER WITH ALECTINIB2025F Hoffmann La Roche AG0
ALECTINIB FOR THE TREATMENT OF ALK FUSION-POSITIVE SOLID OR CNS TUMOURS2025F Hoffmann La Roche AG0
Process for preparing Alectinib or a pharmaceutically acceptable salt thereof2022Fresenius Kabi Oncology Ltd0
A PROCESS FOR PREPARING ALECTINIB OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF2020Fresenius Kabi Oncology Ltd0

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Lung Cancer Treatments and Mutations4
2Salivary Gland Tumors Diagnosis and Treatment1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Peter N. MorcosRoche (United States)17
2Alice T. ShawMassachusetts General Hospital18
3Bogdana BalasRoche (Switzerland)12
4D. Ross CamidgeUniversity of Colorado Denver12
5Makoto NishioJapanese Foundation For Cancer Research12
6Ali ZeaiterRoche (Switzerland)11
7Anne‐Marie C. DingemansErasmus MC Cancer Institute11
8Sai‐Hong Ignatius OuUniversity of California, Irvine11
9James Chih‐Hsin YangNational Taiwan University Hospital8
10Elena GueriniRoche (Switzerland)7

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of Alecensa?

Alecensa has the molecular formula C30H35ClN4O2 and a molecular weight of 519.086. It is also known by the chemical name 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;hydrochloride.

Which organizations hold the most patents related to Alecensa?

Foundation Medicine Inc and Gilead Sciences Inc hold the highest number of patents at 84 and 83 respectively. Other leading patent assignees include Chugai Pharmaceutical Co Ltd with 69 patents and F Hoffmann La Roche AG with 28 patents.

What clinical research has been published on Alecensa in lung cancer?

Multiple high-impact studies have been published on Alecensa in lung cancer treatment. Key papers include a comparison of Alecensa versus Crizotinib in untreated ALK-positive non-small-cell lung cancer (2449 citations), a randomized phase 3 trial comparing the two drugs in the J-ALEX study (912 citations), and studies on safety and activity against brain metastases in crizotinib-resistant patients (695 citations).

Who are the most prolific authors publishing on Alecensa?

Alice T. Shaw has published 18 papers on Alecensa, followed by Peter N. Morcos with 16 papers. Other frequent authors include Bogdana Balas, D. Ross Camidge, and Makoto Nishio, each with 12 publications.

What has been the trend in patent filings for Alecensa in recent years?

Patent activity has increased substantially in recent years. There were 331 patents filed in 2024 and 241 in 2023, compared to only 5 patents in 2016. In the last 3 years, 758 patents have been filed related to Alecensa, demonstrating significant growth in intellectual property development.

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