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Alecensa

9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;hydrochloride · also: C30H35ClN4O2, alectinib HCl, Alecensa (TN), AF-802 hydrochloride, Alectinib Hydrochloride, CH 5424802, Alectinib HCl

FormulaC30H35ClN4O2
Mol. weight519.086
PubChem CID53239799
InChIKeyGYABBVHSRIHYJR-UHFFFAOYSA-N
SMILESCCC1=CC2=C(C=C1N3CCC(CC3)N4CCOCC4)C(C5=C(C2=O)C6=C(N5)C=C(C=C6)C#N)(C)C.Cl
1,147Patents
522Research papers
734Patents - last 3 years
120Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Foundation Medicine Inc84
2Gilead Sciences Inc83
3Chugai Pharmaceutical Co Ltd69
4F Hoffmann La Roche AG28
5Cincinnati Children's Hospital Medical Center25
6The University of Texas System23
7United States Department of Health and Human Services22
8The University of Texas at Austin20
9North Carolina State University17
10Genentech Inc16

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations882
2A61PTherapeutic activity (drug indications)861
3C07KPeptides350
4C07DHeterocyclic compounds320
5C12NMicroorganisms, enzymes197
6C12QMeasuring/testing involving enzymes190
7G16B142
8G01NInvestigating / analysing materials138
9G16HDigital health, healthcare informatics91
10Y02AClimate change adaptation53

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Lung Cancer Treatments and Mutations8
2Heat shock proteins research1
3Salivary Gland Tumors Diagnosis and Treatment1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Peter N. MorcosRoche (United States)17
2Alice T. ShawMassachusetts General Hospital18
3Bogdana BalasRoche (Switzerland)12
4D. Ross CamidgeUniversity of Colorado Denver12
5Makoto NishioJapanese Foundation For Cancer Research12
6Ali ZeaiterRoche (Switzerland)11
7Anne‐Marie C. DingemansErasmus MC Cancer Institute11
8Sai‐Hong Ignatius OuUniversity of California, Irvine11
9James Chih‐Hsin YangNational Taiwan University Hospital8
10Elena GueriniRoche (Switzerland)7

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical composition and molecular weight of Alecensa?

Alecensa has the molecular formula C30H35ClN4O2 with a molecular weight of 519.086. Its canonical chemical name is 9-ethyl-6,6-dimethyl-8-(4-morpholin-4-ylpiperidin-1-yl)-11-oxo-5H-benzo[b]carbazole-3-carbonitrile;hydrochloride, and it is also known by the chemical identifier CH5424802 in its base form.

Which organizations hold the most patents related to Alecensa?

Foundation Medicine Inc and Gilead Sciences Inc are the leading patent assignees, each holding 84 and 83 patents respectively. Chugai Pharmaceutical Co Ltd follows with 69 patents, while F Hoffmann La Roche AG holds 28 patents in this space.

What are the primary research topics associated with Alecensa?

The primary research focus is Lung Cancer Treatments and Mutations, particularly regarding ALK-positive non-small-cell lung cancer. This is reflected in highly-cited papers including studies on alectinib versus crizotinib as treatments and its activity against crizotinib-resistant ALK-rearranged tumors.

Who are the most prolific authors publishing on Alecensa research?

Alice T. Shaw from Massachusetts General Hospital and Peter N. Morcos from Roche (United States) are the leading authors, with 18 and 17 papers respectively. Other prominent researchers include Bogdana Balas, D. Ross Camidge, and Makoto Nishio, each with 12 publications.

How has research and patent activity around Alecensa evolved in recent years?

Both patent and paper output have grown significantly. Patents increased from 14 in 2019 to a peak of 341 in 2024, while papers peaked at 81 in 2021 before stabilizing around 44-52 annually through 2024. The total patent portfolio includes 1,147 patents and 522 papers.

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