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Deoxyadenosine

(2R,3S,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol · also: 2'-dA · desoxyadenosin · Desoxyadenosine · 2-Deoxyadenosine · 2'-deoxyadenosine · 2-deoxy-adenosine

FormulaC10H13N5O3
Mol. weight251.246
PubChem CID13730
InChIKeyOLXZPDWKRNYJJZ-RRKCRQDMSA-N
SMILESC1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)O
22,275Patents
328Research papers327 indexed in detail
4,047Patents - last 3 years
4Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Thermo Fisher Scientific Inc1,114
2Ionis Pharmaceuticals Inc833
3Harvard University694
4University of California393
5Massachusetts Institute of Technology348
6Sanofi SA328
7Roche Holding AG327
8Labcorp Holdings Inc301
9Mass General Brigham Inc287
10Alnylam Pharmaceuticals Inc271

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes10,669
2A61KMedicinal preparations9,347
3A61PTherapeutic activity (drug indications)8,211
4C12QMeasuring/testing involving enzymes6,913
5C07KPeptides5,407
6C07HSugars and derivatives3,352
7G01NInvestigating / analysing materials2,810
8C12YEnzyme nomenclature (EC numbers)2,365
9C07DHeterocyclic compounds1,438
10C12PFermentation, enzyme processes1,371

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis1994Scripps Research Institute62
Method for the production of 2'-deoxyadenosine compounds1988Brigham Young University38
Method for the production of 2'-deoxyadenosine compounds1986Brigham Young University36
2-halo-2'-deoxyadenosines in the treatment of monocyte-mediated inflammatory disease conditions1996Scripps Research Institute24
2-Halo-2'-deoxyadenosines as therapeutic agents against malignant astrocytoma1995Scripps Research Institute19

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
201615
20178
201812
201914
20208
20217
20224
20244

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Jayant S KulkarniWayne State University6
2Yoshio SaitōNihon University5
3Erik De ClercqRega Institute for Medical Research5
4Arun R. WakadeWayne State University5
5Rodney E. KellemsBaylor College of Medicine4
6Piet HerdewijnRega Institute for Medical Research4
7Ashok AgarwalCleveland Clinic4
8Zbigniew J. LeśnikowskiPolish Academy of Sciences4
9Jean CadetCEA Grenoble4
10Maria Grazia TozziUniversity of Pisa4

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of deoxyadenosine?

Deoxyadenosine has the molecular formula C10H13N5O3 and a molecular weight of 251.246 g/mol.

Which organizations have filed the most patents involving deoxyadenosine?

The top patent assignees are Thermo Fisher Scientific Inc with 1114 patents, Ionis Pharmaceuticals Inc with 833 patents, and Harvard University with 694 patents. Other major assignees include University of California, Massachusetts Institute of Technology, and Sanofi SA.

What are the key research topics associated with deoxyadenosine in the academic literature?

Major research topics include epigenetics and DNA methylation, as exemplified by work on N6-deoxyadenosine methylation in mammalian mitochondrial DNA; immune cell mechanisms in cancer; RNA and protein synthesis mechanisms related to phosphorothioation of DNA; and oxidative damage pathways involving peroxynitrite-mediated oxidation of purine bases.

How has patent activity for deoxyadenosine changed in recent years?

Patent filing activity has grown substantially, rising from 814 patents in 2016 to 1882 patents in 2024. The last three years have accounted for 4047 patents out of a total of 22275 patents, reflecting increased research and development focus on this compound.

What therapeutic applications have been explored in deoxyadenosine-related patents?

Patents have explored deoxyadenosine derivatives for treatment of rheumatoid arthritis, monocyte-mediated inflammatory disease conditions, and malignant astrocytoma, as well as methods for production of 2'-deoxyadenosine compounds.

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