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Deoxyadenosine

(2R,3S,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol · also: 2'-dA, desoxyadenosin, Desoxyadenosine, 2-Deoxyadenosine, 2'-deoxyadenosine, 2-deoxy-adenosine

FormulaC10H13N5O3
Mol. weight251.246
PubChem CID13730
InChIKeyOLXZPDWKRNYJJZ-RRKCRQDMSA-N
SMILESC1[C@@H]([C@H](O[C@H]1N2C=NC3=C(N=CN=C32)N)CO)O
22,275Patents
328Research papers
4,226Patents - last 3 years
4Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Ionis Pharmaceuticals Inc832
2Harvard University693
3Life Technologies Corp646
4University of California, San Diego358
5Massachusetts Institute of Technology325
6Sequenom Inc273
7Applied Biosystems Inc251
8Applied Biosystems LLC250
9Oxford Nanopore Technologies PLC225
10University of California Berkeley170

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes10,661
2A61KMedicinal preparations9,340
3A61PTherapeutic activity (drug indications)8,198
4C12QMeasuring/testing involving enzymes6,905
5C07KPeptides5,403
6C07HSugars and derivatives3,352
7G01NInvestigating / analysing materials2,809
8C12YEnzyme nomenclature (EC numbers)2,350
9C07DHeterocyclic compounds1,438
10C12PFermentation, enzyme processes1,370

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis1994Scripps Research Institute62
Method for the production of 2'-deoxyadenosine compounds1988Brigham Young University38
Method for the production of 2'-deoxyadenosine compounds1986Brigham Young University36
2-halo-2'-deoxyadenosines in the treatment of monocyte-mediated inflammatory disease conditions1996Scripps Research Institute24
2-Halo-2'-deoxyadenosines as therapeutic agents against malignant astrocytoma1995Scripps Research Institute19

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1DNA and Nucleic Acid Chemistry2
2Pharmaceutical and Antibiotic Environmental Impacts1
3Sperm and Testicular Function1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Arun R. WakadeWayne State University6
2Erik De ClercqRega Institute for Medical Research6
3Jayant S KulkarniWayne State University6
4Jean CadetCEA Grenoble6
5Azusa SuzukiNihon University5
6Leif KrönbergÅbo Akademi University5
7Ashok AgarwalCleveland Clinic4
8Bolesław T. KarwowskiMedical University of Lodz4
9Jan BalzariniRega Institute for Medical Research4
10Alejandro B. SigueSoliman Fakeeh Hospital3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of deoxyadenosine?

Deoxyadenosine has the molecular formula C10H13N5O3 with a molecular weight of 251.246. Its canonical chemical name is (2R,3S,5R)-5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol.

Which organizations hold the most patents mentioning deoxyadenosine?

The leading patent assignees in this field are Ionis Pharmaceuticals Inc with 832 patents, Harvard University with 693 patents, and Life Technologies Corp with 646 patents. Other significant contributors include University of California, San Diego (358 patents), Massachusetts Institute of Technology (325 patents), and Sequenom Inc (273 patents).

What types of therapeutic applications have been patented for deoxyadenosine derivatives?

Patent filings document several therapeutic applications for deoxyadenosine compounds. The 1994 patent titled '2-halo-2'-deoxyadenosines in the treatment of rheumatoid arthritis' addresses inflammatory disease treatment. Another 1996 patent covers '2-halo-2'-deoxyadenosines in the treatment of monocyte-mediated inflammatory disease conditions', and a 1995 patent addresses '2-Halo-2'-deoxyadenosines as therapeutic agents against malignant astrocytoma'.

What research topics are most prominent in the academic literature on deoxyadenosine?

The primary research focus areas include DNA and Nucleic Acid Chemistry. Notable recent papers include work on N6-Deoxyadenosine Methylation in Mammalian Mitochondrial DNA (2020, 248 citations) and Peroxynitrite Mediated Oxidation of Purine Bases of Nucleosides and Isolated DNA (1996, 178 citations).

How has patenting activity for deoxyadenosine changed in recent years?

Patent filings have shown significant growth in recent years. Annual patent counts increased from 787 in 2018 to 1,847 in 2023, with 1,882 patents filed in 2024. The 3-year patent count through 2024 totals 4,226 patents. In contrast, academic paper output has declined, with only 4 papers published in the last 3 years compared to historical levels.

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