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5-HMF

5-(hydroxymethyl)furan-2-carbaldehyde · also: Hydroxymethylfurfural, Hydroxymethylfurfurole, Glucosamine EP Impurity E, Hydroxymethylfurfuraldehyde, Hydroxymethylfurfuralaldehyde

FormulaC6H6O3
Mol. weight126.111
PubChem CID237332
InChIKeyNOEGNKMFWQHSLB-UHFFFAOYSA-N
SMILESC1=C(OC(=C1)C=O)CO
22,992Patents
1,509Research papers
3,942Patents - last 3 years
126Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Archer Daniels Midland Co443
2Dalian Institute of Chemical Physics of CAS386
3Furanix Technologies BV333
4BASF SE320
5Novozymes Inc320
6IFP Energies Nouvelles IFPEN240
7China Petroleum and Chemical Corp232
8Novozymes AS219
9Shell Internationale Research Maatschappij BV196
10Eastman Chemical Co159

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C07DHeterocyclic compounds6,146
2Y02EClimate change mitigation: energy4,054
3C12PFermentation, enzyme processes4,047
4B01JChemical/physical processes (e.g. catalysts)3,390
5Y02PClimate change mitigation: production3,077
6C07CAcyclic and carbocyclic compounds2,481
7C12NMicroorganisms, enzymes2,143
8A61KMedicinal preparations1,910
9C08GPolymers from non-vinyl bonds (e.g. polyamides, polyesters)1,573
10C13K1,532

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Process for the oxidation of 5-hydroxymethylfurfural1990Hoechst AG128
Process for preparing pure 5-hydroxymethylfurfuraldehyde1988SUDDEUTSCHE ZUCKER-AKTIENGESELLSCHAFT101
Production of 5-hydroxymethylfurfural1960Merck and Co Inc90
Process for manufacturing 5-hydroxymethylfurfural1986Roquette Freres SA81
Process for manufacturing 5-hydroxymethylfurfural1982Roquette Freres SA73

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Catalysis for Biomass Conversion6
2Advanced Glycation End Products research5
3Biofuel production and bioconversion5
4Bee Products Chemical Analysis3
5Phytochemicals and Antioxidant Activities2
6Anaerobic Digestion and Biogas Production1
7Carcinogens and Genotoxicity Assessment1
8Fermentation and Sensory Analysis1
9Natural Antidiabetic Agents Studies1
10Natural Products and Biological Research1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Anders WieslanderLund University10
2Baochang CaiNanjing University of Chinese Medicine8
3Ann Van LoeyKU Leuven6
4Avelino CormaUniversitat Politècnica de València6
5Bärbel Hahn‐HägerdalLund University6
6Cristina Delgado‐AndradeEstación Experimental del Zaidín6
7Reinhold WintersteigerUniversity of Graz6
8Z. Lewis LiuNational Center for Agricultural Utilization Research6
9Andrea B. MaierMedical University of Graz5
10Bernhard H. MonienGerman Institute of Human Nutrition5

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition and structure of 5-HMF?

5-HMF, chemically known as 5-(hydroxymethyl)furan-2-carbaldehyde, has the molecular formula C6H6O3 and a molecular weight of 126.111. It is also known by several synonyms including hydroxymethylfurfural and hydroxymethylfurfuraldehyde.

Which organizations hold the most patents related to 5-HMF technology?

The leading patent holders for 5-HMF are Archer Daniels Midland Co with 443 patents, Dalian Institute of Chemical Physics of CAS with 386 patents, and Furanix Technologies BV with 333 patents. BASF SE and Novozymes Inc each hold 320 patents in this field.

What are the most influential research papers on 5-HMF production?

Highly cited foundational works include a 2007 paper on metal chlorides in ionic liquid solvents converting sugars to 5-hydroxymethylfurfural with 1974 citations, and a 2006 paper on phase modifiers promoting efficient production from fructose with 1655 citations. A 2010 work on ionic liquid-mediated formation has 789 citations, and a 1990 study on formation mechanism from fructose and sucrose has 764 citations.

What are the dominant research topics and patent classifications for 5-HMF?

The dominant patent classification is C07D (heterocyclic compounds) with 6146 patents, followed by Y02E (energy-related patents) with 4054 and C12P (fermentation and enzyme-based processes) with 4047 patents. Primary research topics include catalysis for biomass conversion and biofuel production and bioconversion.

How has patenting activity in 5-HMF technology changed in recent years?

Patent activity in 5-HMF has grown substantially, with 1382 patents filed in 2016 increasing to 1770 in 2024. In the last three years, 4032 patents were filed. Meanwhile, academic publications have remained more stable, with 126 papers published in the last three years out of a total of 1509 papers in the database.

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