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5-HMF

5-(hydroxymethyl)furan-2-carbaldehyde · also: 5-HMF cpd, 5-HM-2-F cpd, 5-methylolfurfural, 5-Oxymethylfurfurole, Hydroxymethylfurfural, Hydroxymethylfurfurole

FormulaC6H6O3
Mol. weight126.111
PubChem CID237332
InChIKeyNOEGNKMFWQHSLB-UHFFFAOYSA-N
SMILESC1=C(OC(=C1)C=O)CO
22,992Patents
1,509Research papers
3,712Patents - last 3 years
126Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Archer Daniels Midland Co443
2Dalian Institute of Chemical Physics386
3Furanix Technologies BV332
4BASF SE320
5Novozymes Inc320
6IFP Energies nouvelles240
7China Petroleum and Chemical Corp232
8Novozymes AS219
9Shell Internationale Research Maatschappij BV196
10Eastman Chemical Co159

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C07DHeterocyclic compounds6,146
2Y02EClimate change mitigation: energy4,057
3C12PFermentation, enzyme processes4,048
4B01JChemical/physical processes (e.g. catalysts)3,391
5Y02PClimate change mitigation: production3,081
6C07CAcyclic and carbocyclic compounds2,481
7C12NMicroorganisms, enzymes2,144
8A61KMedicinal preparations1,910
9C08GPolymers from non-vinyl bonds (e.g. polyamides, polyesters)1,576
10C13K1,532

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Process for the oxidation of 5-hydroxymethylfurfural1990Hoechst AG128
Production of 5-hydroxymethylfurfural1960Merck and Co Inc90
Process for manufacturing 5-hydroxymethylfurfural1986Roquette Freres SA81
Process for manufacturing 5-hydroxymethylfurfural1982Roquette Freres SA73
Process for the manufacture of high purity hydroxymethylfurfural (HMF)1992FURCHIM63

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Biofuel production and bioconversion9
2Catalysis for Biomass Conversion8
3Advanced Glycation End Products research5
4Bee Products Chemical Analysis4
5Mycotoxins in Agriculture and Food2
6Phytochemicals and Antioxidant Activities2
7Anaerobic Digestion and Biogas Production1
8Carcinogens and Genotoxicity Assessment1
9Chemical Reactions and Isotopes1
10Enzyme Catalysis and Immobilization1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

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Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Anders WieslanderLund University10
2Baochang CaiNanjing University of Chinese Medicine8
3Ann Van LoeyKU Leuven6
4Bärbel Hahn‐HägerdalLund University6
5Cristina Delgado‐AndradeEstación Experimental del Zaidín6
6Reinhold WintersteigerUniversity of Graz6
7Vural GökmenHacettepe University6
8Z. Lewis LiuNational Center for Agricultural Utilization Research6
9Andrea B. MaierMedical University of Graz5
10Avelino CormaUniversitat Politècnica de València5

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and structure of 5-HMF?

5-HMF, also known as 5-(hydroxymethyl)furan-2-carbaldehyde, has the molecular formula C6H6O3 with a molecular weight of 126.111. It is a furan-based compound containing both hydroxymethyl and aldehyde functional groups.

Which organizations hold the most patents related to 5-HMF?

The leading patent assignees for 5-HMF include Archer Daniels Midland Co with 443 patents, Dalian Institute of Chemical Physics with 386 patents, and Furanix Technologies BV with 332 patents. Other major holders include BASF SE and Novozymes Inc, each with 320 patents.

What are the primary research topics associated with 5-HMF?

The primary research focus areas include biofuel production and bioconversion, catalysis for biomass conversion, and advanced glycation end products research. These topics reflect 5-HMF's significance as a biomass-derived platform chemical and its relevance to biochemical research.

How has patent activity for 5-HMF evolved recently?

Patent activity has shown growth in recent years, with 1,768 patents filed in 2023 and 1,770 in 2024. Over the last three years, 3,712 patents have been filed. This upward trend reflects increasing industrial and research interest in 5-HMF technologies.

Which highly-cited papers address the production of 5-HMF from sugars?

Notable highly-cited works include the paper on metal chlorides in ionic liquid solvents converting sugars to 5-hydroxymethylfurfural with 1,983 citations, and the work on phase modifiers promoting efficient production from fructose with 1,661 citations. An additional paper on ionic liquid-mediated formation received 792 citations.

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