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5-HMF

5-(hydroxymethyl)furan-2-carbaldehyde · also: 5-HMF cpd · 5-HM-2-F cpd · 5-methylolfurfural · 5-Oxymethylfurfurole · Hydroxymethylfurfural · Hydroxymethylfurfurole

FormulaC6H6O3
Mol. weight126.111
PubChem CID237332
InChIKeyNOEGNKMFWQHSLB-UHFFFAOYSA-N
SMILESC1=C(OC(=C1)C=O)CO
22,992Patents
1,509Research papers
3,538Patents - last 3 years
126Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Chinese Academy of Sciences732
2Novo Nordisk Fonden473
3Archer Daniels Midland Co443
4Avantium NV349
5BASF SE323
6IFP Energies nouvelles280
7Shell PLC270
8China Petrochemical Corp243
9DSM Firmenich AG230
10Eastman Chemical Co192

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C07DHeterocyclic compounds6,146
2Y02EClimate change mitigation: energy4,057
3C12PFermentation, enzyme processes4,049
4B01JChemical/physical processes (e.g. catalysts)3,391
5Y02PClimate change mitigation: production3,082
6C07CAcyclic and carbocyclic compounds2,481
7C12NMicroorganisms, enzymes2,144
8A61KMedicinal preparations1,910
9C08GPolymers from non-vinyl bonds (e.g. polyamides, polyesters)1,576
10C13K1,532

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Process for the oxidation of 5-hydroxymethylfurfural1990Sanofi SA128
Production of 5-hydroxymethylfurfural1960Merck and Co Inc90
Process for manufacturing 5-hydroxymethylfurfural1986Roquette Freres SA81
Process for manufacturing 5-hydroxymethylfurfural1982Roquette Freres SA73
Process for the manufacture of high purity hydroxymethylfurfural (HMF)199263

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
201663
201763
201843
201954
202066
202151
202296
202355
202442
202528
20261

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Gwi‐Taek JeongPukyong National University11
2Gunnar LidénLund University10
3Joachim GreilbergerMedical University of Graz8
4Torbjörn LindénLund University7
5Avelino CormaUniversitat Politècnica de València6
6Chae HunPukyong National University6
7Shujuan YuSouth China University of Technology6
8Vural GökmenHacettepe University6
9Reinhold WintersteigerUniversity of Graz6
10Thomas HenleTechnische Universität Dresden5

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of 5-HMF?

5-HMF has the molecular formula C6H6O3 and a molecular weight of 126.111 g/mol. Its canonical chemical name is 5-(hydroxymethyl)furan-2-carbaldehyde.

Which organizations hold the most patents related to 5-HMF?

The top patent assignees for 5-HMF are Chinese Academy of Sciences with 732 patents, Novo Nordisk Fonden with 473 patents, and Archer Daniels Midland Co with 443 patents. Other significant assignees include Avantium NV with 349 patents and BASF SE with 323 patents.

What is the overall patent and paper coverage for 5-HMF research?

The 5-HMF field has a total of 22,992 patents and 1,509 papers in the database. In the last 3 years, there have been 3,538 new patents and 126 new papers, indicating substantial ongoing research and development activity.

Which CPC subclasses are most frequently associated with 5-HMF patents?

The top five CPC subclasses for 5-HMF patents are: C07D with 6,146 patents, Y02E with 4,057 patents, C12P with 4,049 patents, B01J with 3,391 patents, and Y02P with 3,082 patents. These indicate focus on heterocyclic compound chemistry, energy technology, biotechnology, and chemical engineering.

What has been the trend in 5-HMF patent publications in recent years?

Patent filings for 5-HMF have shown growth from 1,277 patents in 2019 to 1,768 in 2023 and 1,770 in 2024. The most recent complete year (2024) maintained high activity levels, with 1,098 patents filed in 2025 (partial year data).

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