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1-O-Phosphonohex-2-ulose

(3,4,5,6-tetrahydroxy-2-oxohexyl) dihydrogen phosphate · also: L-Sorbose-1-phosphate

FormulaC6H13O9P
Mol. weight260.1348
PubChem CID481
InChIKeyZKLLSNQJRLJIGT-UHFFFAOYSA-N
SMILESC(C(C(C(C(=O)COP(=O)(O)O)O)O)O)O
141Patents
123Research papers
17Patents - last 3 years
0Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Roche Holding AG12
2Sinochem Holdings Corp Ltd8
3Amgen Inc7
4German Cancer Research Center5
5Hebrew University of Jerusalem5
6Novartis AG5
7Hadassah Medical Organization4
8Lonza Group AG4
9Massachusetts Institute of Technology4
10Asahi Kasei Corp3

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes79
2A61KMedicinal preparations43
3A61PTherapeutic activity (drug indications)42
4C12YEnzyme nomenclature (EC numbers)36
5C12PFermentation, enzyme processes26
6C12QMeasuring/testing involving enzymes26
7C07KPeptides25
8G01NInvestigating / analysing materials21
9Y02EClimate change mitigation: energy12
10C07DHeterocyclic compounds11

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES2011Amgen Inc116
POLYCOMB-ASSOCIATED NON-CODING RNAS2012Mass General Brigham Inc96
Substituted 3-azabicyclo [3.1.0] hexanes as ketohexokinase inhibitors2018Pfizer Inc32
2.2-DIFLUOROPROPIONAMIDE DERIVATIVES OF BARDOXOLONE METHYL, POLYMORPHIC FORMS AND METHODS OF USE THEREOF2013Biogen Inc46
PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES2009Roche Holding AG58

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Paul M. StewartUniversity of Birmingham20
2Elizabeth A. WalkerUniversity of Birmingham15
3Gareth G. LaveryUniversity of Birmingham13
4Angelo BenedettiUniversity of Siena11
5Alex OdermattUniversity of Basel10
6Perrin C. WhiteThe University of Texas Southwestern Medical Center9
7Silvia SenesiUniversity of Siena8
8Rosella FulceriUniversity of Siena8
9Gábor BánhegyiSemmelweis University8
10Miklós CsalaSemmelweis University6

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of 1-O-Phosphonohex-2-ulose?

1-O-Phosphonohex-2-ulose has the molecular formula C6H13O9P and a molecular weight of 260.1348. It is also known by the canonical name (3,4,5,6-tetrahydroxy-2-oxohexyl) dihydrogen phosphate.

Which organizations hold the most patents related to this compound?

Roche Holding AG holds the most patents with 12, followed by Sinochem Holdings Corp Ltd with 8 patents, and Amgen Inc with 7 patents. Other significant patent holders include German Cancer Research Center, Hebrew University of Jerusalem, and Novartis AG, each with 5 patents.

What is the trend in patent filings for this compound in recent years?

Patent activity for 1-O-Phosphonohex-2-ulose has increased significantly in recent years. From 2017 to 2019, there were only 1–2 patents per year. Activity accelerated starting in 2020, with 9 patents filed in 2024 and 6 in 2025. Over the last 3 years, 17 patents have been filed in total.

What are the main research topics associated with this compound?

The research literature on this compound focuses on hormonal regulation and hypertension, particularly the relationship between 11β-hydroxysteroid dehydrogenase type 1 and hexose-6-phosphate dehydrogenase. Key papers address glucocorticoid response regulation, cortisone reductase deficiency mutations, and cooperativity mechanisms in the endoplasmic reticulum.

Which patent classifications are most relevant to inventions involving this compound?

The most common patent classifications are C12N (79 patents), followed by A61K (43 patents) and A61P (42 patents). C12Y (36 patents) and C12P (26 patents) are also frequently used, indicating that the compound is heavily associated with biotechnology, pharmaceutical, and chemical processing inventions.

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