Book a demo

Chemical intelligence powered by cypris.ai

2,3-Diphosphoglyceric Acid

(2R)-2,3-diphosphonooxypropanoic acid · also: D-greenwald ester, Diphosphoglycerate, D-Glyceric acid bis, 2,3-diphospho-D-glycerate, Glyceric acid diphosphate, 2,3-bisphospho-D-glycerate

FormulaC3H8O10P2
Mol. weight266.0345
PubChem CID186004
InChIKeyXOHUEYCVLUUEJJ-UWTATZPHSA-N
SMILESC([C@H](C(=O)O)OP(=O)(O)O)OP(=O)(O)O
579Patents
1,435Research papers
21Patents - last 3 years
17Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Merck Patent GmbH163
2BASF SE9
3Baxter Biotech Technology SARL7
4Global Blood Therapeutics Inc7
5University of Toronto Innovations Foundation7
6Exact Sciences Corp6
7University of California, San Diego6
8Columbia University5
9Searete LLC5
10University of Minnesota System5

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

Visit Cypris

Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations398
2A61PTherapeutic activity (drug indications)233
3A61QCosmetics, personal care194
4C07KPeptides101
5C07DHeterocyclic compounds79
6A01NPreservation of bodies; biocides; pest repellents71
7C07CAcyclic and carbocyclic compounds52
8C12NMicroorganisms, enzymes44
9A61MDevices for introducing media into the body36
10A61LSterilising / disinfecting materials34

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

See Cypris in action

Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
METHOD AND COMPOSITION FOR DETERMINING D-GLYCEROALDEHYDE-3-PHOSPHORIC ACID, INOGANIC PHOSPHORUS, OR 1,3-DIPHOSPHOGLYCERIC ACID IN HIGH SENSITIVITY1992Asahi Chemical Industry Co Ltd7
A FORMULATION AND A PROCESS FOR REDUCING THE DETERIORATION OF RBCs OF BLOOD DURING STORAGE WITH PARTICULAR REFERENCE TO DECREASE IN THE LEVEL OF 2,3 DIPHOSPHOGLYCERATE2004CHANDRASEKHAR, BALAGOPAL6
Cosmetic and dermatological formulations using cyclic 2,4-diphosphoglycerate (cDGP) and / or derivatives2004ビトプ アクチェンゲゼルシャフト フューア ビオテヒニシェ オプティミールング4
Application of phthalide compound in preparing medicine for treating Alzheimer disease and abnormal metabolism of 2, 3-diphosphoglycerate2017SUN YAT-SEN UNIVERSITY1
Use of cyclic 2,4-diphosphoglycerate (cDGP) and / or derivatives in cosmetic and dermatological formulations2002BITOP GESELLSCHAFT FUER BIOTECHNISCHE OPTIMIERUNG MBH1

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Hemoglobin structure and function12
2Hemoglobinopathies and Related Disorders7
3Renal function and acid-base balance4
4Amino Acid Enzymes and Metabolism3
5Erythrocyte Function and Pathophysiology3
6Dialysis and Renal Disease Management2
7Enzyme Structure and Function2
8Neonatal Health and Biochemistry2
9Advanced MRI Techniques and Applications1
10Blood disorders and treatments1

Technology trend analysis

Cypris uses AI to connect emerging research themes to IP activity, commercialization signals, and underexplored opportunity areas.

See Cypris in action

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Bruno GiardinaUniversity of Rome Tor Vergata17
2C. R. ValeriUnited States Naval Research Laboratory10
3Claire PoyartBicêtre Hospital10
4Angelo D’AlessandroUniversity of Colorado Denver9
5Alvarez-Sala JlUniversidad Complutense de Madrid8
6A. FransCliniques Universitaires Saint-Luc7
7Claes F. HögmanUppsala University Hospital7
8B. BohnInserm6
9Josep CarrerasUniversitat de Barcelona6
10Roy E. WeberAarhus University6

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

See Cypris in action

The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Operation Everest II: oxygen transport during exercise at extreme simulated altitude1988417Chronic Obstructive Pulmonary Disease (COPD) Research
Respiratory Function of Hemoglobin1998299Neonatal Health and Biochemistry
A Randomized Study of Phosphate Therapy in the Treatment of Diabetic Ketoacidosis*1983246Pancreatic function and diabetes
Sphingosine-1-phosphate promotes erythrocyte glycolysis and oxygen release for adaptation to high-altitude hypoxia2016213Autophagy in Disease and Therapy
The Effect of Sepsis on the Erythrocyte2017199Blood properties and coagulation

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition and structure of 2,3-Diphosphoglyceric Acid?

2,3-Diphosphoglyceric Acid has the molecular formula C3H8O10P2 with a molecular weight of 266.0345. Its canonical IUPAC name is (2R)-2,3-diphosphonooxypropanoic acid. The compound is also known by multiple synonyms including diphosphoglycerate, 2,3-bisphospho-D-glycerate, and D-Glyceric acid bis(dihydrogen phosphate).

Which organizations hold the most patents related to 2,3-Diphosphoglyceric Acid?

Merck Patent GmbH leads with 163 patents, followed by BASF SE with 9 patents and three organizations tied with 7 patents each: Baxter Biotech Technology SARL, Global Blood Therapeutics Inc, and University of Toronto Innovations Foundation.

What are the primary research topics associated with 2,3-Diphosphoglyceric Acid in published literature?

The leading research topic is Hemoglobin structure and function with 12 papers, followed by Hemoglobinopathies and Related Disorders with 7 papers. Other significant areas include Renal function and acid-base balance (4 papers), Amino Acid Enzymes and Metabolism (3 papers), and Erythrocyte Function and Pathophysiology (3 papers).

Who are the leading researchers publishing on 2,3-Diphosphoglyceric Acid?

Bruno Giardina from University of Rome Tor Vergata has published 17 papers on the subject. C. R. Valeri from the United States Naval Research Laboratory and Claire Poyart from Bicêtre Hospital each have 10 publications. Angelo D'Alessandro from University of Colorado Denver follows with 9 papers, and Alvarez-Sala Jl from Universidad Complutense de Madrid has 8 papers.

What is the patent classification landscape for 2,3-Diphosphoglyceric Acid?

The dominant patent classification is A61K (pharmaceutical preparations) with 398 patents, followed by A61P (pharmaceutical use) with 233 patents and A61Q (cosmetic and dermatological preparations) with 194 patents. Chemical classification C07K appears in 101 patents, and C07D in 79 patents, indicating diverse pharmaceutical and cosmetic applications.

Turn any compound into a complete chemical intelligence landscape

Go beyond static compound data. Cypris resolves identities, patents, papers, and commercial signals into one AI-powered view - so your team can move from a single chemical question to a complete R&D, IP, and market landscape.

Schedule a free trial