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VAS2870

2-(3-benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole · also: 3-Benyl-7-(2-benzoxazolyl)yhio-1,2,3-triazolo(4,5-d)pyrimidine, 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo(4,5-d)pyrimidine, 3H-1,2,3-Triazolo(4,5-d)pyrimidine, 7-(2-benzoxazolylthio)-3-(phenylmethyl)-

FormulaC18H12N6OS
Mol. weight360.395
PubChem CID4058452
InChIKeyHZSOKHVVANONPV-UHFFFAOYSA-N
SMILESC1=CC=C(C=C1)CN2C3=C(C(=NC=N3)SC4=NC5=CC=CC=C5O4)N=N2
138Patents
56Research papers
52Patents - last 3 years
2Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Emory University20
2BioNTech SE14
3United States Department of Health and Human Services9
4Verinos Operations GmbH7
5Astellas Pharma Inc6
6Centre National de la Recherche Scientifique5
7Beijing Tongren Hospital4
8Boehringer Ingelheim International GmbH4
9Universiteit Maastricht4
10Cincinnati Children's Hospital Medical Center3

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations119
2A61PTherapeutic activity (drug indications)113
3C07KPeptides35
4C12NMicroorganisms, enzymes31
5C07DHeterocyclic compounds24
6G01NInvestigating / analysing materials19
7C12QMeasuring/testing involving enzymes16
8A61QCosmetics, personal care12
9Y02AClimate change adaptation12
10C12YEnzyme nomenclature (EC numbers)10

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Neuroscience of respiration and sleep1
2Neutrophil, Myeloperoxidase and Oxidative Mechanisms1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Bin LiuCentral South University3
2Jun PengCentral South University3
3Patricia I. OteizaUniversity of California, Davis3
4Adriana V. TreuerUniversity of Talca2
5Daniel R. GonzálezUniversity of Talca2
6Daniel SimõesUniversidade de São Paulo1
7Galina Yu. MironovaKoltzov Institute of Developmental Biology2
8Gang DaiThe First Affiliated Hospital, Sun Yat-sen University2
9Harald SchmidtMonash University2
10Jianwen ChenSun Yat-sen University2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular composition of VAS2870?

VAS2870 has the molecular formula C18H12N6OS with a molecular weight of 360.395. Its canonical chemical name is 2-(3-benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole, and it is also known by several alternative nomenclature forms including 7-(2-benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo(4,5-d)pyrimidine.

Which organizations hold the most patents for VAS2870?

Emory University leads with 20 patents, followed by BioNTech SE with 14 patents and the United States Department of Health and Human Services with 9 patents. Other significant patent holders include Verinos Operations GmbH with 7 patents and Astellas Pharma Inc with 6 patents.

What is the primary biological mechanism of action described in VAS2870 research?

Published research indicates that VAS2870 functions as a Nox inhibitor. Studies demonstrate its ability to attenuate PDGF-dependent smooth muscle cell chemotaxis and inhibit oxLDL-induced reactive oxygen species formation in human endothelial cells. Research also connects VAS2870 to NOX4-dependent mechanisms in inflammasome activation and neuronal autotoxicity.

What are the dominant patent classification areas for VAS2870?

The compound is most heavily classified under A61K (pharmaceutical formulations), with 119 patents in this category. This is closely followed by A61P (therapeutic applications), with 113 patents. Other significant classification areas include C07K with 35 patents, C12N with 31 patents, and C07D with 24 patents.

What is the recent patent activity trend for VAS2870?

Patent filing activity for VAS2870 peaked in 2022 with 33 patents, followed by 27 patents in 2024 and 22 in 2023. In the last three years, there have been 52 patents filed. Academic publishing shows minimal recent activity, with only 2 papers published in the last three years out of a total of 56 papers in the collection.

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