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VAS2870

2-(3-benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole · also: 3-Benyl-7-(2-benzoxazolyl)yhio-1,2,3-triazolo(4,5-d)pyrimidine · 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo(4,5-d)pyrimidine

FormulaC18H12N6OS
Mol. weight360.395
PubChem CID4058452
InChIKeyHZSOKHVVANONPV-UHFFFAOYSA-N
SMILESC1=CC=C(C=C1)CN2C3=C(C(=NC=N3)SC4=NC5=CC=CC=C5O4)N=N2
138Patents
56Research papers
51Patents - last 3 years
2Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Emory University20
2BioNTech SE14
3Government of the United States of America9
4Astellas Pharma Inc8
5Verinos Pharmaceuticals GmbH7
6Centre National de la Recherche Scientifique5
7C.H. Boehringer Sohn AG and Co KG4
8Capital Medical University4
9Universiteit Maastricht4
10Cincinnati Children's Hospital Medical Center3

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1A61KMedicinal preparations119
2A61PTherapeutic activity (drug indications)113
3C07KPeptides35
4C12NMicroorganisms, enzymes31
5C07DHeterocyclic compounds24
6G01NInvestigating / analysing materials19
7C12QMeasuring/testing involving enzymes16
8A61QCosmetics, personal care12
9Y02AClimate change adaptation12
10C12YEnzyme nomenclature (EC numbers)10

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS2022Emory University16
QUINAZOLINE DERIVATIVES, COMPOSITIONS, AND USES RELATED THERETO2012Emory University48
MODIFIED NUCLEOSIDES AND NUCLEOTIDES ANALOGS AS ANTIVIRAL AGENTS FOR CORONA AND OTHER VIRUSES2022Emory University13
THIONUCLEOSIDES AS ANTIVIRAL AGENTS2022Emory University12
FARNESOID X RECEPTOR AGONISTS FOR THE TREATMENT OF DISEASE2020Metacrine Inc16

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20166
20177
20185
201910
20205
20231
20241

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Xiu‐Ju LuoCentral South University3
2Patricia I. OteizaUniversity of California, Davis3
3Daniel R. GonzálezUniversity of Talca2
4Zhong‐Song ShiThe First Affiliated Hospital, Sun Yat-sen University2
5Н. В. ГончаровInstitute of Evolutionary Physiology and Biochemistry2
6Lei FengKaiser Permanente2
7Raúl A DulceUniversity of Miami2
8Mingchang LiWuhan University2
9Maria WartenbergUniversity of Cologne2
10Yong-Hua TuoThe First Affiliated Hospital, Sun Yat-sen University2

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the chemical structure and molecular formula of VAS2870?

VAS2870 has the IUPAC name 2-(3-benzyltriazolo[4,5-d]pyrimidin-7-yl)sulfanyl-1,3-benzoxazole with molecular formula C18H12N6OS and a molecular weight of 360.395 g/mol. The compound is also known by the synonym NOX Inhibitor III, VAS2870.

Which organizations hold the most patents related to VAS2870?

Emory University leads with 20 patents, followed by BioNTech SE with 14 patents and the Government of the United States of America with 9 patents. Other significant patent holders include Astellas Pharma Inc with 8 patents and Verinos Pharmaceuticals GmbH with 7 patents.

What is the patent and publication trend for VAS2870 research?

Patent activity has increased significantly, with 2022 showing 33 patents and 2024 showing 27 patents. Over the last 3 years, there have been 51 patents filed. In contrast, academic publication activity has been minimal, with only 2 papers published in the last 3 years and 56 papers identified in the full dataset spanning 2016 to 2024.

What are the main research topics associated with VAS2870?

Research on VAS2870 focuses on multiple disease areas. Key topics include inflammasome and immune disorders, with papers such as one on NOX4-dependent fatty acid oxidation promoting NLRP3 inflammasome activation in macrophages. Other prominent research areas involve nitric oxide and endothelin effects, with notable studies on NOX inhibition in smooth muscle cell chemotaxis and neuronal protection in ischemic damage.

Which patent classifications dominate VAS2870-related intellectual property?

The most prevalent CPC subclass is A61K (pharmaceutical preparations), appearing in 119 patents, followed closely by A61P (therapeutic uses), appearing in 113 patents. Other significant classifications include C07K (peptide chemistry) with 35 patents, C12N (microorganism/enzyme technology) with 31 patents, and C07D (heterocyclic compounds) with 24 patents.

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