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1-Methyladenosine

(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methylpurin-9-yl)oxolane-3,4-diol · also: N1-Methyladenosine · N(1)-methyladenosine · N1-Methyl-D-adenosine · (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methyl-purin-9-yl)tetrahydrofuran-3,4-diol · (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methyl-6,9-dihydro-1H-purin-9-yl)oxolane-3,4-diol · (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methyl-1H-purin-9(6H)-yl)tetrahydrofuran-3,4-diol

FormulaC11H15N5O4
Mol. weight281.272
PubChem CID27476
InChIKeyGFYLSDSUCHVORB-IOSLPCCCSA-N
SMILESCN1C=NC2=C(C1=N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
4,719Patents
129Research papers
1,141Patents - last 3 years
12Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1Moderna Inc453
2BioNTech SE290
3aTyr Pharma Inc131
4GSK PLC129
5Novartis AG92
6University of Pennsylvania88
7Thermo Fisher Scientific Inc74
8Harvard University69
9Wave Life Sciences Pte Ltd65
10Revvity Inc61

Explore the full landscape

This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes3,233
2A61KMedicinal preparations3,137
3A61PTherapeutic activity (drug indications)2,664
4C07KPeptides1,505
5C12QMeasuring/testing involving enzymes707
6C12YEnzyme nomenclature (EC numbers)677
7G01NInvestigating / analysing materials598
8C07HSugars and derivatives451
9Y02AClimate change adaptation405
10C12PFermentation, enzyme processes259

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Representative patents

The filings that best characterise the patent activity around this compound, most-referenced first.

TitleYearAssigneeCited by
Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine20012

How research activity has moved

Papers published per year for this compound, over the last decade of indexed records.

YearPapers
20168
201710
20189
201915
20208
20219
20223
20231
20248
20253

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Michinao MizugakiTohoku University Hospital10
2Nakao IshidaTohoku University8
3Kunihiko ItohTohoku University Hospital7
4Qing DaiUniversity of Chicago6
5Tao PanUniversity of Chicago5
6Chengqi YiPeking University5
7Shunji IshiwataTohoku University Hospital5
8Xushen XiongPeking University4
9Xiaoyu LiPeking University4
10Mark HelmJohannes Gutenberg University Mainz3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Post-transcriptional gene regulation by mRNA modifications20162561RNA and protein synthesis mechanisms
The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA20161066RNA and protein synthesis mechanisms
Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome2016717Cancer-related molecular mechanisms research
The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution2017674Cancer-related molecular mechanisms research
ALKBH1-Mediated tRNA Demethylation Regulates Translation2016602Epigenetics and DNA Methylation

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of 1-Methyladenosine?

1-Methyladenosine has the molecular formula C11H15N5O4 and a molecular weight of 281.272 g/mol.

Which organizations hold the most patents related to 1-Methyladenosine?

The leading patent assignees are Moderna Inc with 453 patents, BioNTech SE with 290 patents, aTyr Pharma Inc with 131 patents, GSK PLC with 129 patents, and Novartis AG with 92 patents.

What research topics are most frequently associated with 1-Methyladenosine publications?

The most prominent research topics include RNA and protein synthesis mechanisms and cancer-related molecular mechanisms research. Key papers address post-transcriptional gene regulation by mRNA modifications, the N1-methyladenosine methylome in eukaryotic messenger RNA, and transcriptome-wide mapping of N1-methyladenosine methylation.

How has patent activity related to 1-Methyladenosine changed in recent years?

Patent activity has grown substantially, with 172 patents in 2016 increasing to 654 in 2024. The growth accelerated notably from 2022 (468 patents) through 2024 (654 patents), representing a significant upward trend over the past three years.

What diagnostic applications have been patented for 1-Methyladenosine?

A diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine was patented in 2001, demonstrating early clinical interest in detecting this compound.

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