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1-Methyladenosine

(2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methylpurin-9-yl)oxolane-3,4-diol · also: N1-Methyladenosine, N(1)-methyladenosine, Adenosine, 1-methyl-, N1-Methyl-D-adenosine, Adenosine, 1-methyl- (VAN), Adenosine, N,6-didehydro-1,6-dihydro-1-methyl-

FormulaC11H15N5O4
Mol. weight281.272
PubChem CID27476
InChIKeyGFYLSDSUCHVORB-IOSLPCCCSA-N
SMILESCN1C=NC2=C(C1=N)N=CN2[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O
4,719Patents
129Research papers
1,203Patents - last 3 years
12Papers - last 3 years

Who owns the IP

The organizations most actively patenting around this compound, ranked by referenced patent volume.

#AssigneePatents
1ModernaTx Inc374
2CureVac SE249
3GlaxoSmithKline Biologicals SA129
4Pangu Biopharma Ltd123
5aTyr Pharma Inc117
6University of Pennsylvania83
7Moderna Inc79
8Thermo Fisher Scientific Inc71
9Harvard University69
10Dharmacon Inc61

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This preview shows the leading assignees. Cypris reveals the full ownership landscape - every filing entity, filing trends, and portfolio momentum.

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Where innovation is concentrated

Patent classifications ranked by volume reveal the technical domains with the most active filing.

#CodeAreaPatents
1C12NMicroorganisms, enzymes3,224
2A61KMedicinal preparations3,134
3A61PTherapeutic activity (drug indications)2,662
4C07KPeptides1,500
5C12QMeasuring/testing involving enzymes705
6C12YEnzyme nomenclature (EC numbers)672
7G01NInvestigating / analysing materials598
8C07HSugars and derivatives451
9Y02AClimate change adaptation404
10C12PFermentation, enzyme processes259

AI mapped opportunity space

This preview shows where patent activity concentrates. Cypris maps the full classification landscape to surface technical whitespace and IP headroom.

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Most-cited patents

Patents ranked by forward citations reveal the foundational inventions the field continues to build on.

TitleYearAssigneeCited by
Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine2001NYXIS NEUROTHERAPIES, INC.2

Where research is gaining momentum

Research themes ranked by publication activity show where scientific interest is accelerating around this compound.

#Research topicPapers
1Geography and Environmental Studies1
2RNA and protein synthesis mechanisms1
3RNA modifications and cancer1

Who's driving the science

The most-published authors working with this compound, alongside their primary affiliations.

#AuthorAffiliationPapers
1Michinao MizugakiTohoku University Hospital10
2Kunihiko ItohTohoku University Hospital9
3Nakao IshidaTohoku University9
4Chengqi YiPeking University5
5Chuan HeUniversity of Chicago5
6Qing DaiUniversity of Chicago5
7Shunji IshiwataTohoku University Hospital5
8Claudia HöbartnerUniversity of Würzburg3
9Dan DominissiniTel Aviv University3
10Eikan MishimaTohoku University3

Research leaders

This preview lists the top authors. Cypris surfaces the full researcher landscape, their affiliations, and how scientific influence is shifting.

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The literature that defines it

The most-cited papers anchoring the scientific record for this compound.

TitleYearCited byTopic
Post-transcriptional gene regulation by mRNA modifications20162563RNA and protein synthesis mechanisms
The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA20161058RNA and protein synthesis mechanisms
Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome2016714Cancer-related molecular mechanisms research
The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution2017669Cancer-related molecular mechanisms research
ALKBH1-Mediated tRNA Demethylation Regulates Translation2016597Epigenetics and DNA Methylation

Frequently asked questions

Common questions about this compound's patent and research landscape, answered from the underlying data.

What is the molecular formula and weight of 1-Methyladenosine?

1-Methyladenosine has the molecular formula C11H15N5O4 and a molecular weight of 281.272 Da. Its canonical IUPAC name is (2R,3S,4R,5R)-2-(hydroxymethyl)-5-(6-imino-1-methylpurin-9-yl)oxolane-3,4-diol.

Which organizations hold the most patents related to 1-Methyladenosine?

ModernaTx Inc leads with 374 patents, followed by CureVac SE with 249 patents and GlaxoSmithKline Biologicals SA with 129 patents. Academic institutions also contribute significantly, including University of Pennsylvania with 83 patents and Harvard University with 69 patents.

What are the main research topics associated with 1-Methyladenosine publications?

Research on 1-Methyladenosine focuses primarily on RNA and protein synthesis mechanisms, including post-transcriptional gene regulation by mRNA modifications and transcriptome-wide mapping of N1-methyladenosine methylation. Cancer-related molecular mechanisms research is also a significant research area.

What patent application relates to diagnostic detection of 1-Methyladenosine?

Patent US-6274314-B1, titled 'Diagnostic assay for the modified nucleosides pseudouridine, 7-methyladenosine, or 1-methyladenosine', was issued in 2001 and covers diagnostic applications for detecting 1-methyladenosine alongside other modified nucleosides.

How has patent activity involving 1-Methyladenosine evolved in recent years?

Patent activity has shown significant growth, with 237 patents in 2020, rising to 601 in 2023 and 654 in 2024. The last three years (2023-2025) account for 1,203 of the total 4,719 patents, indicating accelerating interest in this compound across biotechnology and pharmaceutical applications.

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